dr. W.L.J. (Wouter) Hinrichs
Working experience
Oct. 1998-Present
Department of Pharmaceutical Technology and Biopharmacy, University of Groningen, The Netherlands, headed by Prof. Dr. H.W. Frijlink.
Main research subjects:
- Sugar glasses for the stabilization of biopharmaceuticals.
- Solid dispersions for the stabilization and improved bioavailability of lipophilic drugs.
- Powders for pulmonary delivery and tablets for oral administration.
- Controlled release of biopharmaceuticals from biodegradable polymeric matrices
Co-promotor
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Candidate |
Title thesis |
Date PhD defense |
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Blends of trehalose and pullulan to stabilize biopharmaceuticals in alternative dosage forms: Orodispersible films and dissolving microneedles |
23 October 2020 |
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Biodegradable implants for the biphasic pulsatile delivery of antigens: Towards single-injection vaccines |
16 October 2020 |
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siRNA in precision-cut lung slices: knocking down fibrosis? |
20 December 2019 |
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Osteoprotegerin in organ fibrosis: biomarker, actor and target of therapy? |
17 June 2019 |
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Paving the way for pulmonary influenza vaccines: Exploring formulations, models and site of deposition |
7 December 2018 |
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Towards improved and broadly protective influenza vaccines; Focus on delivery systems, routes of administration and animal models |
8 October 2018 |
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Protein delivery from polymeric matrices: From pre-formulation stabilization studies to site-specific delivery |
20 April 2018 |
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Delivery of biologicals: Sustained release of cell-specific proteins in fibrosis |
23 March 2018 |
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Solid state stabilization of proteins by sugars: Why size and flexibility matter |
2 June 2017 |
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Development of solid dispersion formulation containing curcumin/curcuma longa standardized extract to improve curcumin dissolution rate and absorption |
3 February 2016 |
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Improving protein stabilization by spray drying: Formulation and process development |
11 January 2016 |
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Innovative platform technologies for stabilization and controlled release of proteins from polymer depots |
8 December 2014 |
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Powder to the people; The storage stability, handling, and administration advantages of powder formulations for pulmonary vaccination |
5 December 2014 |
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New strategies for simplifying influenza vaccination |
9 May 2014 |
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Development of adjuvanted influenza vaccines for pulmonary delivery |
15 February 2014 |
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Innovative strategies for stabilization of therapeutic peptides in aqueous formulations |
2 July 2012 |
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Improved dissolution behavior of lipophilic drugs by solid dispersions: a matter of composition |
18 April 2011 |
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A novel bottom-up process to prepare drug nanocrystals: The art of the soluble |
11 March 2011 |
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Novel perspectives for influenza vaccine formulation and administration: L. lactis cell wall derived adjuvant, stable dry powder vaccines and mucosal vaccine delivery |
3 December 2010 |
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Dry powder inhalation of biopharmaceuticals: From formulation to proof of concept |
11 December 2009 |
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The development of stable influenza vaccine powder formulations for new needle-free dosage forms |
4 January 2008 |
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Combining the incompatible: Inulin glass dispersions for fast dissolution, stabilization and formulation of lipophilic drugs |
28 April 2006 |
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Analytical techniques and formulation strategies for the therapeutic protein alkaline phosphatase |
5 July 2004 |
- Faculty of Pharmacy, Universitas Gadjah Mada, Yogyakarta, Indonesia
Teaching:
Theoretical courses:
- Thermodynamics (1998-present)
- Transport through membranes (2003- 2007)
- Physical chemistry of colloids, suspensions and emulsions (2000-present)
- Formulation proteins and lipophilic drugs (2011-present)
Practical courses:
- Technology and Biopharmacy (1998-2008)
- Dispensing and Dosage Forms (1998-2008)
- Pharmaceutical Technology and Biopharmacy (2008-present)
Other:
- Editorial board/academic editor “Pharmaceutics” (2018-present).
- Scientific coordinator “Biopharmacy Day”: (bi)annual meeting of the Belgium and Dutch Society for Pharmaceutical Technology and Biopharmaceutical Sciences (2005-2008 and 2012-present).
- Theoretical course entitled “Physicochemical aspects related to dosage form development” for master students Industrial Pharmacy. Facultas Farmasi, Universitas Surabaya, Indonesia (2014-present).
- Member of the board of the Dutch Federation for Pharmaceutical Sciences (2005-2012).
- Principal investigator Top Institute Pharma project entitled: “Hot Medicines: breaking the cold chain requirement for polypeptide-based priority medicines (2008-2012).
- Principle investigator of W.J. Kolff Institute, UMCG, Groningen, The Netherlands (2011-present).
- Principle investigator of ANDDI program, UMCG, Groningen, The Netherlands (2011-2013).
- Advanced course on pharmaceutical technology: Application of dispersion system on improving drug stability. Facultas Farmaci, Universitas Surabaya, Indonesia, July 20-22, 2006.
- Reviewer for journals:
- AapsPharmSciTech
- ACS Applied Materials & Interfaces
- ACS Biomaterials Science & Engineering
- Applied Microbiology and Biotechnology
- Applied Science
- Biochimica et Biophysica Acta
- Biophysical Journal
- Coatings
- Colloids and Surfaces A
- Current Research in Pharmacology and Drug Discovery
- Drug Development and Industrial Pharmacy
- Drying Technology
- Enzyme and Microbial Technology
- European Journal of Pharmaceutics and Biopharmaceutics
- European Journal of Pharmaceutical Sciences
- Expert Opinion on Drug Delivery
- Expert Reviews on Vaccines
- Industrial & Engineering Chemistry Research
- International Journal of Biological Macromolecules
- International Journal of Inflammation
- International Journal of Nanomedicine
- International Journal of Pharmaceutics
- Journal of Biomaterials Science: Polymer Edition
- Journal of Controlled Release
- Journal of Food Engineering
- Journal of Drug Delivery Science and Technology
- Journal of Peptide Science
- Molecular Pharmaceutics
- Molecules
- Pharmaceutical Research
- Pharmaceuticals
- Pharmaceutics
- Polymers
- Polymers International
- Powder Technology
- Therapeutic Delivery
- Vaccine
- Vaccines
January 2004 - June 2004
Sabbatical leave. Laboratory of General Biochemistry and Physical Pharmacy, Ghent University, Belgium, headed by Prof. Dr. S.C. De Smedt and Prof. Dr. J. Demeester.
Research subject:
- Sugar glasses for the stabilization of nanoparticles (liposomes and gene delivery systems).
November 1996 - September 1998
Department of Biopharmacy and Pharmaceutical Technology, Utrecht University, The Netherlands, headed by Prof. Dr. Ir. W.E. Hennink.
Research subjects:
- Thermosensitive polymers as carriers for DNA delivery
- Polymers as adhesives for oral prostheses
- Thermosensitive hydrogels for the controlled release of proteins
Teaching:
- Theoretical course “Thermodynamics and Kinetics”
November 1992 - October 1996
Institute for Biomedical Technology, University of Twente, The Netherlands, headed by Prof. Dr. J. Feijen.
Research subject:
- Improved biocompatibility of heamodialysis membranes by covalent coupling of heparin.
Education
Doctorate study
January 1987 - November 1992
Institute for Biomedical Technology, University of Twente, The Netherlands, under supervision of Prof. Dr. J. Feijen and Department of Experimental Cardiopulmonary Surgery, University Hospital of Groningen, The Netherlands under supervision of Prof. Dr. Ch.R.H. Wildevuur.
Title of PhD thesis: Porous Polymer Structures for Tissue Regeneration.
Masters study
September 1977 - January 1985
Chemistry at the University of Groningen, The Netherlands. Main subjects: inorganic chemistry and human genetics.
| Laatst gewijzigd: | 25 juni 2022 16:18 |