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Over ons Praktische zaken Waar vindt u ons prof. dr. F. (Folkert) Kuipers

Research interests

 

- Physiology and pathophysiology of the enterohepatic circulation in humans and experimental animals: hepatic and intestinal transport systems, mechanisms of bile formation and cholestasis, (patho)physiology of biliary lipid secretion, metabolic control by bile acids via newly identified signaling cascades

- Hepatic lipid metabolism in humans and experimental animals: lipoprotein assembly and secretion, causes and consequences of hepatic steatosis, interactions between carbohydrate and lipid metabolism, inborn errors of metabolism, inflammatory pathways, role of nuclear receptors (LXR, CHREBP)

- Regulation of cholesterol synthesis and trafficking: transcription factors and nuclear receptors (SREBP/PPAR/FXR/LXR) and transporter proteins, perinatal development, metabolic programming, application of stable isotope approaches

- Quantification of metabolic fluxes by stable isotope procedures

 

Publicaties

Changes in bile acid composition are correlated with reduced intestinal cholesterol uptake in intestine-specific WASH-deficient mice

Characterization of milk oligosaccharide and sialic acid content and their influence on brain sialic acid in a lean mouse model for gestational diabetes

Comparative Analysis of Digestion Methods for Bile Proteomics: The Key to Unlocking Biliary Biomarker Potential

Corrigendum to “Adipocyte-specific FXR-deficiency protects adipose tissue from oxidative stress and insulin resistance and improves glucose homeostasis” [Mol Metab 69 (2023) 1–13]

Dietary cystine restriction increases the proliferative capacity of the small intestine of mice

Elevated plasma bile acids coincide with cardiac stress and inflammation in young Cyp2c70−/− mice

Oral Anaerobutyricum soehngenii augments glycemic control in type 2 diabetes

Reversal of insulin resistance in people with obesity by lifestyle-induced weight loss does not impact the proportion of circulating 12α-hydroxylated bile acids

Supplementation of Seaweed Extracts to the Diet Reduces Symptoms of Alzheimer's Disease in the APPswePS1ΔE9 Mouse Model

Transmission and dynamics of mother-infant gut viruses during pregnancy and early life

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Pers/media

Verouderingsproces tegenhouden

Journal News - From the Journals

De rol van het microbioom bij het ontstaan van hart- en vaatziekten

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