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University Medical Center Groningen

prof. dr. F. (Folkert) Kuipers

Profielfoto van prof. dr. F. (Folkert) Kuipers
E-mail:
f.kuipers umcg.nl
Research interests Publicaties Pers/media

Research interests

 

- Physiology and pathophysiology of the enterohepatic circulation in humans and experimental animals: hepatic and intestinal transport systems, mechanisms of bile formation and cholestasis, (patho)physiology of biliary lipid secretion, metabolic control by bile acids via newly identified signaling cascades

- Hepatic lipid metabolism in humans and experimental animals: lipoprotein assembly and secretion, causes and consequences of hepatic steatosis, interactions between carbohydrate and lipid metabolism, inborn errors of metabolism, inflammatory pathways, role of nuclear receptors (LXR, CHREBP)

- Regulation of cholesterol synthesis and trafficking: transcription factors and nuclear receptors (SREBP/PPAR/FXR/LXR) and transporter proteins, perinatal development, metabolic programming, application of stable isotope approaches

- Quantification of metabolic fluxes by stable isotope procedures

 

Publicaties

Changes in bile acid composition are correlated with reduced intestinal cholesterol uptake in intestine-specific WASH-deficient mice

Heida, A., van Dijk, T., Smit, M., Koehorst, M., Koster, M., Kloosterhuis, N., Havinga, R., Bloks, V. W., Wolters, J. C., de Bruin, A., Kuivenhoven, J. A., de Boer, J. F., Kuipers, F. & van de Sluis, B., mrt.-2024, In: Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. 1869, 2, 11 blz., 159445.

Onderzoeksoutput › › peer review

Characterization of milk oligosaccharide and sialic acid content and their influence on brain sialic acid in a lean mouse model for gestational diabetes

Liu, F., Tol, A. J. C., Kuipers, F., Oosterveer, M. H., van der Beek, E. M. & van Leeuwen, S. S., 15-feb.-2024, In: Heliyon. 10, 3, 13 blz., e24539.

Onderzoeksoutput › › peer review

Comparative Analysis of Digestion Methods for Bile Proteomics: The Key to Unlocking Biliary Biomarker Potential

Thorne, A. M., Hoekzema, M., Porte, R. J., Kuipers, F., de Meijer, V. E. & Wolters, J. C., 2024, In: Analytical Chemistry. 96, 36, blz. 14393–14404 12 blz.

Onderzoeksoutput › › peer review

Corrigendum to “Adipocyte-specific FXR-deficiency protects adipose tissue from oxidative stress and insulin resistance and improves glucose homeostasis” [Mol Metab 69 (2023) 1–13]

Dehondt, H., Marino, A., Butruille, L., Mogilenko, D. A., Nzoussi Loubota, A. C., Chávez-Talavera, O., Dorchies, E., Vallez, E., Haas, J., Derudas, B., Bongiovanni, A., Tardivel, M., Kuipers, F., Lefebvre, P., Lestavel, S., Tailleux, A., Dombrowicz, D., Caron, S. & Staels, B., jul.-2024, In: Molecular metabolism. 85, 1 blz., 101961.

Onderzoeksoutput

Dietary cystine restriction increases the proliferative capacity of the small intestine of mice

de Jong, J. C. W., van Rooijen, K. S., Stigter, E. C. A., Gülersönmez, M. C., de Zoete, M. R., Top, J., Baars, M. J. D., Vercoulen, Y., Kuipers, F., van Mil, S. W. C. & Ijssennagger, N., 5-jan.-2024, In: PLoS ONE. 19, 1, 15 blz., e0290493.

Onderzoeksoutput › › peer review

Elevated plasma bile acids coincide with cardiac stress and inflammation in young Cyp2c70−/− mice

de Vries, H. D., Eijgenraam, T. R., Bloks, V. W., Mulder, N. L., van Zutphen, T., Silljé, H. H. W., Kuipers, F. & de Boer, J. F., 2-okt.-2024, (E-pub ahead of print) In: Pediatric Research. 8 blz.

Onderzoeksoutput › › peer review

Glycodeoxycholic acid inhibits primary bile acid synthesis with minor effects on glucose- and lipid homeostasis in humans

Meessen, E. C. E., Majait, S., Ay, Ü., Olde Damink, S. W., Romijn, J. A., Holst, J. J., Hartmann, B., Kuipers, F., Nieuwdorp, M., Schaap, F. G., Groen, A. K., Kemper, E. M. & Soeters, M. R., 12-jun.-2024, (E-pub ahead of print) In: Journal of Clinical Endocrinology and Metabolism.

Onderzoeksoutput › › peer review

Longevity biotechnology: bridging AI, biomarkers, geroscience and clinical applications for healthy longevity

Lyu, Y. X., Fu, Q., Wilczok, D., Ying, K., King, A., Antebi, A., Vojta, A., Stolzing, A., Moskalev, A., Georgievskaya, A., Maier, A. B., Olsen, A., Groth, A., Simon, A. K., Brunet, A., Jamil, A., Kulaga, A., Bhatti, A., Yaden, B. & Pedersen, B. K.& 32 anderen, Schumacher, B., Djordjevic, B., Kennedy, B., Chen, C., Huang, C. Y., Correll, C. U., Murphy, C. T., Ewald, C. Y., Chen, D., Valenzano, D. R., Sołdacki, D., Erritzoe, D., Meyer, D., Sinclair, D. A., Chini, E. N., Teeling, E. C., Morgen, E., Verdin, E., Vernet, E., Pinilla, E., Fang, E. F., Bischof, E., Mercken, E. M., Finger, F., Kuipers, F., Pun, F. W., Gyülveszi, G., Civiletto, G., Kirkland, J. L., Veenhoff, L. M., Scheibye-Knudsen, M. & Bakula, D., 31-okt.-2024, In: Aging. 16, 20, blz. 12955-12976 22 blz.

Onderzoeksoutput › › peer review

Oral Anaerobutyricum soehngenii augments glycemic control in type 2 diabetes

Attaye, I., Witjes, J. J., Koopen, A. M., van der Vossen, E. W. J., Zwirs, D., Wortelboer, K., Collard, D., Kemper, E. M., Winkelmeijer, M., Holst, J. J., Hazen, S. L., Kuipers, F., Stroes, E. S. G., Groen, A. K., de Vos, W. M., Nieuwdorp, M. & Herrema, H., 16-aug.-2024, In: Iscience. 27, 8, 14 blz., 110455.

Onderzoeksoutput › › peer review

Reversal of insulin resistance in people with obesity by lifestyle-induced weight loss does not impact the proportion of circulating 12α-hydroxylated bile acids

Palmiotti, A., Berk, K. A., Koehorst, M., Hovingh, M. V., Pranger, A. T., van Faassen, M., de Boer, J. F., van der Valk, E. S., van Rossum, E. F. C., Mulder, M. T. & Kuipers, F., sep.-2024, In: Diabetes, Obesity and Metabolism. 26, 9, blz. 4019-4029 11 blz.

Onderzoeksoutput › › peer review

Lees meer

Pers/media

Verouderingsproces tegenhouden

Kuipers, F.

21/08/2024 → 23/08/2024

Pers / media: Expert Comment ›

Journal News - From the Journals

Kuipers, F.

01/10/2019

Pers / media: Overig ›

De rol van het microbioom bij het ontstaan van hart- en vaatziekten

Koonen, D. & Kuipers, F.

01/05/2019

Pers / media: Onderzoek ›

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