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Over ons Praktische zaken Waar vindt u ons dr. D.C.J. Spierings

Research interests

Single cell sequencing, genome instability, structural variations, ageing, stem cells, cancer, immunology

Publicaties

Chromosomal instability in aneuploid acute lymphoblastic leukemia associates with disease progression

Chronic spindle assembly checkpoint activation causes myelosuppression and gastrointestinal atrophy

Drug-resilient cancer cell phenotype is acquired via polyploidization associated with early stress response coupled to HIF-2α transcriptional regulation

Extra centrosomes delay DNA damage-driven tumorigenesis

Genome-wide forward genetic screening to identify receptors and proteins mediating nanoparticle uptake and intracellular processing

Inhalable Textile Microplastic Fibers Impair Airway Epithelial Differentiation

MDM2 amplification in rod-shaped chromosomes provides clues to early stages of circularized gene amplification in liposarcoma

Mixed responses to targeted therapy driven by chromosomal instability through p53 dysfunction and genome doubling

Transcriptional differences between vesicular hand eczema and atopic dermatitis

Tunable DNMT1 degradation reveals DNMT1/DNMT3B synergy in DNA methylation and genome organization

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Pers/media

Death receptors in normal and malignant tissues