Dr. Roland Chiu
MSc at BC Cancer Research Centre, University of British Columbia, PhD at the department of Radiation Oncology at the University of California, Los Angeles
I reserach the DNA damage response in cancer treatment
2024
de
Ruiter, N., Wittingslow, R., & Chiu,
R. (Eds.) (2024). Strange Bedfellows: An
Experiment in Student-directed Interdisciplinary
Research. University of Groningen Press. https://doi.org/10.21827/6399d913c9fa9
2022
de
Ruiter, N., Wittingslow, R., & Chiu,
R. (2024). Introduction: Making Strange. In N.
de Ruiter, R. Wittingslow, & R. Chiu (Eds.), Strange
Bedfellows: An Experiment in Student-directed Interdisciplinary
Research (pp. 9-19). University of Groningen Press.
van
der Weide, H. L., Kłos, J.,
Langendijk, J. A., Brouwer, C. L.,
Sinnige, P. F., Borra, R. J. H., Dierckx,
R. A. J. O., Huitema, R. B., Rakers, S.
E., Buunk, A. M., Spikman, J.
M., Bosma, I. B., Enting, R. H.,
Blandhol, M., Chiu, R. K., van der Hoorn,
A., & Kramer, M. C. A. (2022).
Clinical relevance of the radiation dose bath in lower grade
glioma, a cross-sectional pilot study on neurocognitive and
radiological outcome. Clinical and Translational
Radiation Oncology, 33, 99-105. https://doi.org/10.1016/j.ctro.2022.02.001
2019
Wang,
D., Nagle, P. W., Wang, H. H., Smit, J. K., Faber,
H., Baanstra, M., Karrenbeld, A.,
Chiu, R. K., Plukker, J. T. M., &
Coppes, R. P. (2019). Hedgehog Pathway as a Potential
Intervention Target in Esophageal Cancer.
Cancers, 11(6), Article 821. https://doi.org/10.3390/cancers11060821
2016
Nagle,
P. W., Hosper, N. A., Ploeg, E. M., van Goethem,
M.-J., Brandenburg, S., Langendijk, J.
A., Chiu, R. K., & Coppes, R.
P. (2016). The In Vitro Response of Tissue Stem
Cells to Irradiation With Different Linear Energy Transfers.
International Journal of Radiation Oncology Biology
Physics, 95(1), 103-111. https://doi.org/10.1016/j.ijrobp.2016.02.020
Mohiuddin,
U., Kobayashi, S., Keka, I. S., Guilbaud, G., Sale, J., Narita, T.,
Abdel-Aziz, H. I., Wang, X., Ogawa, S., Sasanuma, H., Chiu,
R., Oestergaard, V. H., Lisby, M., & Takeda, S. (2016).
The role of HERC2 and RNF8 ubiquitin E3 ligases in the
promotion of translesion DNA synthesis in the chicken DT40 cell
line. Dna repair, 40, 67-76.
https://doi.org/10.1016/j.dnarep.2016.02.002
Wang,
D., Chiu, R., Coppes, R., &
Plukker, J. T. H. M. (2016). The role of mTOR
inhibitors in targeting a putative cancer stem cell-like population
in esophageal cancer. Journal of Clinical
Oncology, 34(suppl 4), 43. https://doi.org/10.1200/jco.2016.34.4_suppl.43
2015
Wang,
D., Smit, J., Chiu, R., Plukker,
J., & Coppes, R. (2015). Hedgehog
Pathway Regulates a Putative Cancer Stem Cell-like Population in
Esophageal Cancer. Annals of Surgical
Oncology, 22, S152-S152.
Kobayashi,
S., Kasaishi, Y., Nakada, S., Takagi, T., Era, S., Motegi,
A., Chiu, R. K., Takeda, S., & Hirota, K. (2015).
Rad18 and Rnf8 facilitate homologous recombination by two
distinct mechanisms, promoting Rad51 focus formation and
suppressing the toxic effect of nonhomologous end joining.
Oncogene, 34(33), 4403-4411. https://doi.org/10.1038/onc.2014.371
Nagle,
P., Hosper, N., Ploeg, E., van Goethem,
M.-J., Langendijk, H., Chiu, R., &
Coppes, R. (2015). The response of
three-dimensional spheroids to particle radiotherapy.
Abstract from Annual NVRB Spring Meeting , Utrecht,
Netherlands.
Wang,
D., Smit, J., Chiu, R., Plukker, J.
T., & Coppes, R. P. (2015).
Unraveling the regulation of a putative cancer stem cell-like
population in esophageal cancer. Journal of
Clinical Oncology, 33(3). https://doi.org/10.1200/jco.2015.33.3_suppl.77
2014
Schults,
M. A., Sanen, K., Godschalk, R. W., Theys, J., van Schooten, F.
J., & Chiu, R. K. (2014). Hypoxia diminishes
the detoxification of the environmental mutagen
benzo[a]pyrene. Mutagenesis,
29(6), 481-487. https://doi.org/10.1093/mutage/geu034
Ramaekers,
C. H. M. A., van den Beucken, T., Bristow, R. G., Chiu, R.
K., Durocher, D., & Wouters, B. G. (2014).
RNF8-Independent Lys63 Poly-Ubiquitylation Prevents Genomic
Instability in Response to Replication-Associated DNA
Damage. PLoS ONE, 9(2),
Article e89997. https://doi.org/10.1371/journal.pone.0089997
Nagle,
P., van Goethem, M.-J., van Luijk,
P., Langendijk, J. A., Coppes,
R., & Chiu, R. (2014). Targeting
DNA repair to enhance particle radiotherapy treatment.
Abstract from 40th Annual meeting of the European Radiation
Research Society, Rhodes, Greece.
2013
Schults,
M. A., Chiu, R. K., Nagle, P., Kleinjans, J. C., van
Schooten, F. J., & Godschalk, R. W. (2013). Genetic
polymorphisms in catalase and CYP1B1 determine DNA adduct formation
by bento(a)pyrene ex vivo.
Mutagenesis, 28(2), 181-185. https://doi.org/10.1093/mutage/ges070
Schults,
M. A., Oligschlaeger, Y., Godschalk, R. W., van Schooten, F.
J., & Chiu, R. (2013). Loss of VHL in RCC
reduces repair and alters cellular response to
bento[a]pyrene. Frontiers in Oncology,
3, Article 270. https://doi.org/10.3389/fonc.2013.00270
2012
Schults,
M. A., Nagle, P. W., Rensen, S. S., Godschalk, R. W., Munnia, A.,
Peluso, M., Claessen, S. M., Greve, J. W., Driessen, A., Verdam, F.
J., Buurman, W. A., van Schooten, F. J., & Chiu, R.
K. (2012). Decreased nucleotide excision repair in
steatotic livers associates with
myeloperoxidase-immunoreactivity. Mutation
research-Fundamental and molecular mechanisms of
mutagenesis, 736(1-2), 75-81. https://doi.org/10.1016/j.mrfmmm.2011.11.001
Niemantsverdriet,
M., Nagle, P., Chiu, R. K., Langendijk, J.
A., Kampinga, H. H., & Coppes, R.
P. (2012). Delta Np73 Enhances Promoter Activity of
TGF-beta Induced Genes. PLoS ONE,
7(12), Article e50815. https://doi.org/10.1371/journal.pone.0050815
2011
Chiu,
R., Schults, M. A., Godschalk, R. W., & van Schooten, F.
J. (2011). Mechanisms involved in the HIF1 mediated
acceleration of chemical carcinogenicity. Abstract from
Annual meeting American Association for Cancer Research , Orlando,
United States.
2010
Schults,
M. A., Timmermans, L., Godschalk, R. W., Theys, J., WOUTERS, B.,
van Schooten, F. J., & Chiu, R. (2010).
Diminished Carcinogen Detoxification Is a Novel Mechanism for
Hypoxia-inducible Factor 1-mediated Genetic Instability.
J Biol Chem, 285(19), 14558-14564.
https://doi.org/10.1074/jbc.M109.076323
Güngör,
N., Knaapen, A., Munnia, A., Peluso, M., Haenen, G. R. M. M.,
Chiu, R., Godschalk, R. W., & van Schooten, F. J.
(2010). Genotoxic effects of neutrophils and hypochlorous
acid. Mutagenesis, 25(2),
149-154. https://doi.org/10.1093/mutage/gep053
gungor,
N., Haegens, A., Knaapen, A., Godschalk, R. W., Chiu,
R., Wouters, E. F. M., & van Schooten, F. J. (2010).
Lung inflammation is associated with reduced pulmonary
nucleotide excision repair in vivo.
Mutagenesis, 25(11), 77-82. https://doi.org/10.1093/mutage/gep049
Brun,
J., Chiu, R., Wouters, B. G., & Gray, D. A.
(2010). Regulation of PCNA polyubiquitination in human
cells. BMC Research Notes, 3,
Article 85. https://doi.org/10.1186/1756-0500-3-85
Güngör,
N., Pennings, J. L. A., Knaapen, A., Chiu, R., Peluso,
M., Godschalk, R. W., & van Schooten, F. J. (2010).
Transcriptional profiling of the acute pulmonary inflammatory
response induced by LPS: role of neutrophils.
Respiratory Research, 11(24),
Article 24. https://doi.org/10.1186/1465-9921-11-24
2009
Chiu,
R., Schults, M. A., Godschalk, R. W., Knaapen, A., Wouters,
B. G., & van Schooten, F. J. (2009). Influence of
hypoxia and HIF1 on carcinogen metabolism as a mechanism for
genetic instability. Abstract from 13th World
Conference on Lung Cancer, San Francisco, United States.
Theys,
J., Jutten, B., Dubois, L., Rouschop, K. M. A., Chiu, R.
K., Li, Y., Paesmans, K., Lambin, P., Lammering, G., &
Wouters, B. G. (2009). The deletion mutant EGFRvIII
significantly contributes to stress resistance typical for the
tumour microenvironment. Radiotherapy and
Oncology, 92(3), 399-404. https://doi.org/10.1016/j.radonc.2009.06.017
2008
Brun,
J., Chiu, R., Lockhart, K., Xiao, W., Wouters, B. G.,
& Gray, D. A. (2008). hMMS2 serves a redundant role in
human PCNA polyubiquitination. BMC Molecular
Biology, 9, Article 24. https://doi.org/10.1186/1471-2199-9-24
2007
Aerts,
H. J. W. L., Dubois, L., Hackeng, T. M., Straathof, R., Chiu,
R. K., Lieuwes, N. G., Jutten, B., Weppler, S. A.,
Lammering, G., Wouters, B. G., & Lambin, P. (2007).
Development and evaluation of a cetuximab-based imaging probe
to target EGFR and EGFRvIII. Radiotherapy and
Oncology, 83(3), 326-32. https://doi.org/10.1016/j.radonc.2007.04.030
Chiu,
R., & Wouters, B. G. (2007). Evaluating the
importance of apoptosis and other determinants of cell death and
survival. In Cancer drug discovery and development:
Apoptosis, senescence and cancer Humana Press.
Langie,
S. A. S., Knaapen, A. M., Ramaekers, C. H. M. A., Theys, J., Brun,
J., Godschalk, R. W. L., van Schooten, F. J., Lambin, P., Gray, D.
A., Wouters, B. G., & Chiu, R. K. (2007).
Formation of lysine 63-linked poly-ubiquitin chains protects
human lung cells against benzo[a]pyrene-diol-epoxide-induced
mutagenicity. Dna repair,
6(6), 852-62. https://doi.org/10.1016/j.dnarep.2007.02.012
Dubois,
L., Douma, K., Supuran, C. T., Chiu, R. K., van
Zandvoort, M. A. M. J., Pastoreková, S., Scozzafava, A.,
Wouters, B. G., & Lambin, P. (2007). Imaging the hypoxia
surrogate marker CA IX requires expression and catalytic activity
for binding fluorescent sulfonamide inhibitors.
Radiotherapy and Oncology, 83(3),
367-373. https://doi.org/10.1016/j.radonc.2007.04.018
Mengesha,
A., Dubois, L., Chiu, R. K., Paesmans, K., Wouters, B.
G., Lambin, P., & Theys, J. (2007). Potential and
limitations of bacterial-mediated cancer therapy.
Frontiers in Bioscience, 12,
3880-91.
2006
Mengesha,
A., Dubois, L., Lambin, P., Landuyt, W., Chiu, R. K.,
Wouters, B. G., & Theys, J. (2006). Development of a
flexible and potent hypoxia-inducible promoter for tumor-targeted
gene expression in attenuated Salmonella. Cancer
biology & therapy, 5(9), 1120-8. https://doi.org/10.4161/cbt.5.9.2951
Chiu,
R. K., Brun, J., Ramaekers, C., Theys, J., Weng, L., Lambin,
P., Gray, D. A., & Wouters, B. G. (2006). Lysine
63-polyubiquitination guards against translesion synthesis-induced
mutations. PLoS genetics,
2(7), 1070-1083. Article 116. https://doi.org/10.1371/journal.pgen.0020116
2003
Wouters,
B. G., Koritzinsky, M., Chiu, R. K., Theys, J.,
Buijsen, J., & Lambin, P. (2003). Modulation of cell
death in the tumor microenvironment. Seminars in
radiation oncology, 13(1), 31-41. https://doi.org/10.1053/srao.2003.50004
2002
Wouters,
B. G., Weppler, S. A., Koritzinsky, M., Landuyt, W., Nuyts, S.,
Theys, J., Chiu, R. K., & Lambin, P. (2002).
Hypoxia as a target for combined modality treatments.
European Journal of Cancer, 38(2),
240-57.
Hayes,
G. M., Chiu, R., Carpenito, C., Dougherty, S. T.,
& Dougherty, G. J. (2002). Identification of sequence
motifs responsible for the adhesive interaction between exon
v10-containing CD44 isoforms. The Journal of
Biological Chemistry, 277(52), 50529-34. https://doi.org/10.1074/jbc.M206719200
2001
Wouters,
B. G., Delahoussaye, Y. M., Evans, J. W., Birrell, G. W., Dorie, M.
J., Wang, J., MacDermed, D., Chiu, R. K., & Brown,
J. M. (2001). Mitochondrial dysfunction after aerobic
exposure to the hypoxic cytotoxin tirapazamine.
Cancer Research, 61(1),
145-52.
Tsirigotis,
M., Zhang, M., Chiu, R. K., Wouters, B. G., &
Gray, D. A. (2001). Sensitivity of mammalian cells expressing
mutant ubiquitin to protein-damaging agents. The
Journal of Biological Chemistry, 276(49),
46073-46078. https://doi.org/10.1074/jbc.M109023200
1999
Chiu,
R. K., Droll, A., Dougherty, S. T., Carpenito, C., Cooper,
D. L., & Dougherty, G. J. (1999). Alternatively spliced
CD44 isoforms containing exon v10 promote cellular adhesion through
the recognition of chondroitin sulfate-modified CD44.
Experimental Cell Research, 248(1),
314-321. https://doi.org/10.1006/excr.1999.4391
Chiu,
R. K., Carpenito, C., Dougherty, S. T., Hayes, G. M., &
Dougherty, G. J. (1999). Identification and characterization
of CD44RC, a novel alternatively spliced soluble CD44 isoform that
can potentiate the hyaluronan binding activity of cell surface
CD44. Neoplasia, 1(5),
446-452. https://doi.org/10.1038/sj.neo.7900045
1995
Droll,
A., Dougherty, S. T., Chiu, R. K., Dirks, J. F.,
McBride, W. H., Cooper, D. L., & Dougherty, G. J. (1995).
Adhesive interactions between alternatively spliced CD44
isoforms. The Journal of Biological
Chemistry, 270(19), 11567-73.
Chiu,
R. K., Droll, A., Cooper, D. L., Dougherty, S. T., Dirks, J.
F., & Dougherty, G. J. (1995). Molecular mechanisms
regulating the hyaluronan binding activity of the adhesion protein
CD44. JOURNAL OF NEURO-ONCOLOGY,
26(3), 231-9.
1994
Dougherty,
G. J., Cooper, D. L., Memory, J. F., & Chiu, R. K.
(1994). Ligand binding specificity of alternatively spliced
CD44 isoforms. Recognition and binding of hyaluronan by
CD44R1. The Journal of Biological
Chemistry, 269(12), 9074-8.
1993
Miller,
A. R., McBride, W. H., Dubinett, S. M., Dougherty, G. J., Thacker,
J. D., Shau, H., Kohn, D. B., Moen, R. C., Walker, M. J.,
& Chiu, R. (1993). Transduction of human melanoma
cell lines with the human interleukin-7 gene using
retroviral-mediated gene transfer: comparison of immunologic
properties with interleukin-2. Blood,
82(12), 3686-94.
| Last modified: | 27 May 2024 4.55 p.m. |