The RNA-Binding Protein NONO Coordinates Hepatic Adaptation to Feeding

by:

Giorgia Benegiamo, Ludovic S. Mure, Galina Erikson, Hiep D. Le, Ermanno Moriggi, Steven A. Brown, Satchidananda Panda

In Brief:

Benegiamo et al. identify a metabolic role for the nuclear RNA-binding protein NONO. Upon feeding, NONO binds to pre-mRNAs of genes involved in glucose and fat metabolism in the liver, regulating their rhythmic expression posttranscriptionally. NONO-deficient mice exhibit disruptions in this temporal regulation and shift from glucose storage to fat oxidation.

Highlights:

• Upon feeding, NONO-containing speckle-like structures increase in liver cell nuclei
• The number of target RNAs bound by NONO increases upon feeding
• NONO binds and regulates the rhythmicity of metabolic genes post-transcriptionally
• NONO is required for normal glucose and lipid homeostasis in mice

Cell Metabolism :January 24, 2018