The New Key Publication of Lianmin Chen: Cover story of Cell Reports, October 6, 2020

On the cover: Bile acids are implicated in the etiology of obesity-related conditions such as non-alcoholic fatty liver disease. In this issue, Chen et al. use an integrative multi-omics approach to highlight the remarkable inter-individual variations of plasma and fecal bile acid profiles within humans with obesity and their linkages with genetic background, the gut microbiome, liver fat content, and circulating lipids. Pictured is a rainbow image of individual bile acid profiles. Image by Lianmin Chen.

Bile acids have been implicated in the etiology of obesity-related conditions in humans, such as insulin resistance, hyperlipidemia, NAFLD and NASH, via FXR and TGR5 signaling. Differently structured primary and secondary human bile acids exert variable signaling activities. In this systematic study, Chen et al. define genetic and microbial associations to plasma and fecal bile acid concentrations and composition in obese humans and establish their relationships to liver fat content and lipid phenotypes

BY:

• Lianmin Chen
• Inge C. L. van den Munckhof
• Kiki Schraa
• Rob ter Horst
• Martijn Koehorst
• Martijn van Faassen
• Claude van der Ley
• Marwah Doestzada
• Daria V. Zhernakova
• Alexander Kurilshikov
• Vincent W. Bloks
• Albert K. Groen
• Human Functional Genomics Project, Niels P. Riksen
• Joost H. W. Rutten
• Leo A. B. Joosten
• Cisca WijmengaAl
• exandra Zhernakova
• Mihai G. Netea
• Jingyuan Fu
• Folkert Kuipers

The paper: Genetic and microbial associations to plasma and fecal bile acids in obese humans relate to plasma lipids and liver fat content