PhD defence M. (Mojgan) Hadian

Innovative high throughput medicinal chemistry

The thesis of Mojgan Hadian demonstrated the employment of high throughput synthesis in medicinal chemistry through multicomponent reaction (MCR).

Hadian: 'Medicinal Chemistry is the science of the discovery and design of new therapeutic chemicals and their progress into applicable medicines. Medicinal chemistry may involve synthesis of new compounds and investigations of their biological activities. It focuses on the hit-to-lead-to-candidate modification process in order to improve its properties. Organic chemistry is the backbone of the medicinal chemistry and has made tremendous progress over the past century. Multicomponent reaction (MCR) is a particular branch of organic chemistry which is the combination of three or more reactants in a one-pot, as opposed to conventional reactions in which only one or two reactants are involved. Recently, MCR chemistry has attracted popularity in pharmaceutical industry.High-throughput synthesis (HTS) referred to running multiple reactions in parallel to create a high-quality data set for the purposes of testing. High-throughput synthesis (HTS) has revolutionized the pharmaceutical industry, due to the rapid screening of compound libraries against therapeutic targets.The fast and efficient approach to biologically relevant compounds through MCRs and diversity of the building blocks have directed the application of MCRs in medicinal chemistry and drug design.'

Promotors: Prof.dr. A.S.S. Domling and Prof.dr. M.R. Groves