Otto, prof. dr. Sijbren
(Foto: Sylvia Germes)
Sijbren Otto is hoogleraar Systeemchemie. Hij bestudeert ‘chemische evolutie’. Zijn onderzoeksgroep ontwikkelde een modelsysteem met moleculen die kopieën van zichzelf kunnen maken en toonde aan dat er ook diversiteit kan ontstaan door mutatie van de replicatoren.
De chemie heeft zich tot nu toe vooral gericht op het laten ontstaan van stabiele systemen. Biologische systemen bestaan echter bij de gratie van vorming en verval, van synthese en degradatie, van een opeenvolging van leven en dood. Sijbren Otto wil onderzoeken of deze biologische principes ook toepasbaar zijn in de synthetische chemie. Zelf-assemblerende en zelf-replicerende macromoleculen spelen daarbij een belangrijke rol. Kunstmatige chemische systemen van dergelijke moleculen zouden ook een Darwiniaanse evolutie kunnen ondergaan. Een eerste stap in de richting van synthetisch leven, hoopt Otto.
Otto kreeg in 2017 een prestigieuze ERC-subsidie van 2,5 miljoen om de mogelijkheden om nieuw leven te maken in het laboratorium verder te onderzoeken. Hij wil verdere stappen zetten om de kloof tussen scheikunde en biologie te overbruggen door volledig synthetische systemen te bouwen. Deze dragen essentiële karakteristieken van het leven in zich: replicatie, metabolisme en compartimentering. Het koppelen van deze karakteristieken in een volledige synthetisch systeem is tot nog toe niet gelukt. In 2020 is Otto benoemd tot lid van de Koninklijke Nederlandse Akademie van Wetenschappen.
In 2021 ontving Otto de James Flack Norris Award in Physical Organic Chemistry van de American Chemical Society, voor zijn leidende bijdrage aan de totstandkoming van het vakgebied van de systeemchemie. Ben Feringa (in 2007) was tot nu toe de enige Nederlander die deze prijs heeft ontvangen.
In oktober 2023 maakte de European Research Council bekend een ERC Synergy Grant toe te kennen aan Otto van 3,4 miljoen euro voor zijn project ‘MINILIFE’.
Bekijk hier een overzicht van het werk van Sijbren Otto over het bouwen van kunstmatig leven. Of bekijk een visueel verhaal van Sijbren Otto's werk.
Meer video's
Eerder in het nieuws
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Leven brouwen in het lab (De Volkskrant, 12 sept. 2020)
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Complexiteit ontstaat zonder evolutie of ontwerp, RUG/Science Linx 17 januari 2019
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Professor Sijbren Otto wint eervolle Royal Society of Chemistry Award, nieuwsbericht RUG 8 mei 2018
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Evoluerende moleculen tonen hoe leven werkt , RUG/Science Linx 19 april 2017
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Twee ERC Advanced Grants voor RUG-onderzoekers , nieuwsbericht RUG 29 maart 2017
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Sijbren Otto and the Origin of Life , bericht RUG 7 januari 2016
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De oorsprong van chemische soorten , RUG/Science Linx 4 januari 2016
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Leven maken in het lab , RUG/Science Linx 17 maart 2015
Meer informatie en contact
Zie de profielpagina en Wikipeda
Publicaties
2024
Markovitch,
O., Wu, J., & Otto, S. (2024).
Binding of Precursors to Replicator Assemblies Can Improve
Replication Fidelity and Mediate Error Correction.
Angewandte Chemie (International ed. in
English), 63(14), Article e202317997. https://doi.org/10.1002/anie.202317997
Brasnett,
C., Kiani, A., Sami, S.,
Otto, S., & Marrink, S. J. (2024).
Capturing chemical reactions inside biomolecular condensates
with reactive Martini simulations. Communications
chemistry, 7(1), Article 151. https://doi.org/10.1038/s42004-024-01234-y
Cvrtila,
I., & Otto, S. (Accepted/In press). Emergent
Behavior of a Photoswitchable Solute in a Biphasic Solvent
System. Chemistry – A European
Journal, Article e202403157. https://doi.org/10.1002/chem.202403157
Komáromy,
D., Monzón, D. M., Marić, I., Monreal
Santiago, G., Ottelé, J., Altay, M.,
Schaeffer, G., & Otto, S. (2024).
Generalist versus Specialist Self-Replicators.
Chemistry – A European Journal,
30(20), Article e202303837. https://doi.org/10.1002/chem.202303837
2023
Ashkenasy,
G., Kauffman, S., Lancet, D., Otto, S., Ruiz-Mirazo,
K., Semenov, S., & Xavier, J. (2023). Collectively
autocatalytic sets. Cell Reports Physical
Science, 4(10), Article 101594. https://doi.org/10.1016/j.xcrp.2023.101594
Yang,
S., Geiger, Y., Geerts, M.,
Eleveld, M. J., Kiani, A., & Otto,
S. (2023). Enantioselective Self-Replicators.
Journal of the American Chemical Society,
145(30), 16889-16898. https://doi.org/10.1021/jacs.3c05472
Liu,
K., Blokhuis, A., van Ewijk, C.,
Kiani, A., Wu, J., Roos, W.
H., & Otto, S. (2023). Light-driven
eco-evolutionary dynamics in a synthetic replicator system.
Nature Chemistry. https://doi.org/10.1038/s41557-023-01301-2
Jin,
Y., Mandal, P. K., Wu, J., Böcher, N., Huc,
I., & Otto, S. (2023). (Re-)Directing
Oligomerization of a Single Building Block into Two Specific
Dynamic Covalent Foldamers through pH. Journal of
the American Chemical Society, 145(5),
2822-2829. https://doi.org/10.1021/jacs.2c09325
Marić,
I., Yang, L., Li, X., Monreal Santiago,
G., Pappas, C. G., Qiu, X.,
Dijksman, J. A., Mikhailov, K., van Rijn,
P., & Otto, S. (2023). Tailorable and
Biocompatible Supramolecular-Based Hydrogels Featuring two Dynamic
Covalent Chemistries. Angewandte Chemie
(International ed. in English), 62(14),
Article e202216475. https://doi.org/10.1002/anie.202216475
2022
Otto,
S. (2022). An Approach to the De Novo Synthesis of
Life. Accounts of Chemical Research,
55(2), 145-155. https://doi.org/10.1021/acs.accounts.1c00534
Hatai,
J., Altay, Y., Sood, A., Kiani,
A., Eleveld, M. J., Motiei, L., Margulies,
D., & Otto, S. (2022). An Optical Probe for
Real-Time Monitoring of Self-Replicator Emergence and
Distinguishing between Replicators. Journal of the
American Chemical Society, 144(7), 3074-3082.
https://doi.org/10.1021/jacs.1c11594
Liu,
K., Ottelé, J., & Otto, S.
(2022). Emergent Catalysis by Self-Replicating
Molecules. In P. W. N. M. van Leeuwen, & M. Raynal
(Eds.), Supramolecular Catalysis: New Directions and
Developments (pp. 605-614). Wiley. https://doi.org/10.1002/9783527832033.ch41
Liu,
B., Wu, J., Geerts, M., Markovitch,
O., Pappas, C. G., Liu, K.,
& Otto, S. (2022). Out-of-equilibrium
self-replication allows selection for dynamic kinetic stability in
a system of competing replicators. Angewandte
Chemie (International ed. in English), 61(18),
Article e202117605. https://doi.org/10.1002/anie.202117605
Camprubi,
E., Markovitch, O., Muchowska, K. B., Otto,
S., & ten Kate, I. L. (2022). Prebiotic chemistry:
From dust to molecules and beyond. In New Frontiers in
Astrobiology (pp. 19-47). Elsevier. https://doi.org/10.1016/B978-0-12-824162-2.00005-1
Bartolec,
B., Kiani, A., Beatty, M. A., Altay,
M., Monreal Santiago, G., & Otto, S.
(2022). Selection of diverse polymorphic structures from a
small dynamic molecular network controlled by the
environment. Chemical Science,
13(48), 14300-14304. https://doi.org/10.1039/d2sc03909e
Schaeffer,
G., Eleveld, M. J., Ottelé,
J., Kroon, P. C., Frederix, P. W. J. M., Yang,
S., & Otto, S. (2022). Stochastic Emergence
of Two Distinct Self-Replicators from a Dynamic Combinatorial
Library. Journal of the American Chemical
Society, 144(14), 6291-6297. https://doi.org/10.1021/jacs.1c12591
Maric,
I., Otto, S., & Pappas, C.
(2022). Tailor-made functionalized
self-assembled peptide (nano)fibers and hydrogels, and methods,
uses and kits related thereto. (Patent No.
WO2022211624).
Matysiak,
B. M., Monreal Santiago, G., & Otto,
S. (2022). Teaching an Old Compound New Tricks:
Reversible Transamidation in Maleamic Acids.
Chemistry - A European Journal,
28(40), Article e202201043. https://doi.org/10.1002/chem.202201043
2021
Yang,
S., Schaeffer, G., Mattia, E., Markovitch,
O., Liu, K., Hussain, A. S., Ottelé,
J., Sood, A., & Otto, S.
(2021). Chemical Fueling Enables Molecular Complexification
of Self-Replicators. Angewandte Chemie -
International Edition, 60(20), 11344-11349. https://doi.org/10.1002/anie.202016196
Liu,
K., & Otto, S. (2021). Dynamic Combinatorial
Chemistry Out of Equilibrium. In N. Giuseppone, & A.
Walther (Eds.), Out-of-Equilibrium (Supra)molecular Systems and
Materials (pp. 215-239). Wiley. https://doi.org/10.1002/9783527821990.ch8
Liu,
B., Beatty, M. A., Pappas, C. G., Liu,
K., Ottelé, J., & Otto, S.
(2021). Self-Sorting in Dynamic Combinatorial Libraries Leads
to the Co-Existence of Foldamers and Self-Replicators.
Angewandte Chemie - International Edition,
60(24), 13569-13573. https://doi.org/10.1002/anie.202101052
Komáromy,
D., Tiemersma-Wegman, T., Kemmink,
J., Portale, G., Adamski, P.
R., Blokhuis, A., Aalbers, F.
S., Marić, I., Santiago, G.
M., Ottelé, J., Sood, A.,
Saggiomo, V., Liu, B., van der Meulen, P., &
Otto, S. (2021). Stoichiometry alone can steer
supramolecular systems on complex free energy surfaces with high
selectivity. Chem, 7(7),
1933-1951. https://doi.org/10.1016/j.chempr.2021.05.020
Pappas,
C. G., Liu, B., Marić, I.,
Ottelé, J., Kiani, A., van der Klok,
M. L., Onck, P. R., & Otto, S.
(2021). Two Sides of the Same Coin: Emergence of Foldamers
and Self-Replicators from Dynamic Combinatorial Libraries.
Journal of the American Chemical Society,
143(19), 7388–7393. https://doi.org/10.1021/jacs.1c00788
2020
Markovitch,
O., Ottele, J., Veldman, O., & Otto,
S. (2020). Automated device for continuous stirring
while sampling in liquid chromatography systems.
Communications chemistry, 3(1),
Article 180. https://doi.org/10.1038/s42004-020-00427-5
Maity,
S., Ottelé, J., Santiago, G.
M., Frederix, P. W. J. M., Kroon, P.,
Markovitch, O., Stuart, M. C. A.,
Marrink, S. J., Otto, S., & Roos, W.
H. (2020). Caught in the Act: Mechanistic Insight into
Supramolecular Polymerization-Driven Self-Replication from
Real-Time Visualization. Journal of the American
Chemical Society, 142(32), 13709-13717. https://doi.org/10.1021/jacs.0c02635
Ottelé,
J., Hussain, A. S., Mayer,
C., & Otto, S. (2020). Chance
emergence of catalytic activity and promiscuity in a
self-replicator. Nature Catalysis,
3(7), 547-553. https://doi.org/10.1038/s41929-020-0463-8
Markovitch,
O., Kramer, B. H., Weissing, F.
J., van Doorn, G. S., & Otto,
S. (2020). Competition dynamics in a chemical system
of self-replicating macrocycles. In J. Bongard, J. Lovato,
L. Hebert-Dufrésne, R. Dasari, & L. Soros (Eds.),
Artificial Life Conference Proceedings (Vol. 32, pp.
462-464). MIT Press. https://doi.org/10.1162/isal_a_00289
Monreal
Santiago, G., Liu, K., Browne, W. R.,
& Otto, S. (2020). Emergence of light-driven
protometabolism on recruitment of a photocatalytic cofactor by a
self-replicator. Nature Chemistry,
12(7), 603-607. https://doi.org/10.1038/s41557-020-0494-4
Pappas,
C. G., Mandal, P. K., Liu, B., Kauffmann, B., Miao, X.,
Komáromy, D., Hoffmann, W., Manz, C., Chang, R., Liu,
K., Pagel, K., Huc, I., & Otto, S. (2020).
Emergence of low-symmetry foldamers from single
monomers. Nature Chemistry,
12(12), 1180-1186. https://doi.org/10.1038/s41557-020-00565-2
Adamski,
P., Eleveld, M., Sood, A., Kun,
Á., Szilágyi, A., Czárán, T., Szathmáry,
E., & Otto, S. (2020). From self-replication
to replicator systems en route to de novo life.
Nature reviews chemistry, 4(8),
386-403. https://doi.org/10.1038/s41570-020-0196-x
Liu,
B., Pappas, C. G., Ottelé, J.,
Schaeffer, G., Jurissek, C., Pieters, P. F., Altay, M.,
Marić, I., Stuart, M. C. A., & Otto,
S. (2020). Spontaneous Emergence of Self-Replicating
Molecules Containing Nucleobases and Amino Acids.
Journal of the American Chemical Society,
142(9), 4184-4192. https://doi.org/10.1021/jacs.9b10796
2019
Liu,
B., Pappas, C. G., Zangrando, E., Demitri, N.,
Chmielewski, P. J., & Otto, S. (2019).
Complex Molecules That Fold Like Proteins Can Emerge
Spontaneously. Journal of the American Chemical
Society, 141(4), 1685-1689. https://doi.org/10.1021/jacs.8b11698
Malakoutikhah,
M., Schaeffer, G., Monreal Santiago, G.,
Yang, S., Maric, I., & Otto, S.
(2019). Cross-Catalysis between Self-Replicators of Different
Handedness. Journal of Systems
Chemistry, 7(1).
Bartolec,
B., Leonetti, G., Li, J., Smit, W., Altay, M., Monreal
Santiago, G., Yan, Y., & Otto, S. (2019).
Emergence of Compartments Formed from Unconventional
Surfactants in Dynamic Combinatorial Libraries.
Langmuir, 35(17), 5787-5792. https://doi.org/10.1021/acs.langmuir.8b03662
2018
Altay,
Y., Altay, M., & Otto, S. (2018). Existing
Self-Replicators Can Direct the Emergence of New Ones.
Chemistry, 24(46), 11911-11915. https://doi.org/10.1002/chem.201803027
Altay,
M., Altay, Y., & Otto, S. (2018). Parasitic
Behavior of Self-Replicating Molecules. Angewandte
Chemie (International ed. in English), 57(33),
10564-10568. https://doi.org/10.1002/anie.201804706
Bartolec,
B., Altay, M., & Otto, S. (2018).
Template-promoted self-replication in dynamic combinatorial
libraries made from a simple building block.
Chemical Communications, 54(93),
13096-13098. https://doi.org/10.1039/c8cc06253f
2017
Matysiak,
B. M., Nowak, P., Cvrtila, I., Pappas, C. G., Liu, B.,
Komáromy, D., & Otto, S. (2017).
Antiparallel Dynamic Covalent Chemistries.
Journal of the American Chemical Society,
139(19), 6744-6751. https://doi.org/10.1021/jacs.7b02575
van
Esch, J. H., Klajn, R., & Otto, S. (2017).
Chemical systems out of equilibrium.
Chemical Society Reviews, 46(18),
5474-5475. Article C7CS90088K. https://doi.org/10.1039/c7cs90088k
Komáromy,
D., Tezcan, M., Schaeffer, G., Marić,
I., & Otto, S. (2017).
Effector-Triggered Self-Replication in Coupled
Subsystems. Angewandte Chemie - International
Edition, 56(46), 14658-14662. https://doi.org/10.1002/anie.201707191
Altay,
Y., Tezcan, M., & Otto, S. (2017). Emergence
of a New Self-Replicator from a Dynamic Combinatorial Library
Requires a Specific Pre-Existing Replicator.
Journal of the American Chemical Society,
139(39), 13612-13615. Article jacs.7b07346. https://doi.org/10.1021/jacs.7b07346
Mattia,
E., Pal, A., Leonetti, G., & Otto, S. (2017).
Mechanism of Building Block Exchange in Stacks of
Self-Replicating Macrocycles. Synlett,
28(1), 103-107. https://doi.org/10.1055/s-0036-1589709
Otto,
S. (2017). Reaction: Thinking-Species Chemistry and
the World's Problems. Chem,
2(2), 158-159. https://doi.org/10.1016/j.chempr.2017.01.018
Cvrtila,
I., Fanlo-Virgós, H., Schaeffer, G.,
Monreal Santiago, G., & Otto, S. (2017).
Redox Control over Acyl Hydrazone Photoswitches.
Journal of the American Chemical Society,
139(36), 12459-12465. Article jacs.7b03724. https://doi.org/10.1021/jacs.7b03724
Komáromy,
D., Stuart, M. C. A., Monreal Santiago,
G., Tezcan, M., Krasnikov, V. V., & Otto,
S. (2017). Self-Assembly Can Direct Dynamic Covalent
Bond Formation Towards Diversity or Specificity.
Journal of the American Chemical Society,
139(17), 6234-6241. https://doi.org/10.1021/jacs.7b01814
Frederix,
P. W. J. M., Idé, J., Altay, Y., Schaeffer,
G., Surin, M., Beljonne, D., Bondarenko, A. S.,
Jansen, T. L. C., Otto, S., &
Marrink, S. J. (2017). Structural and Spectroscopic
Properties of Assemblies of Self-Replicating Peptide
Macrocycles. Acs Nano, 11(8),
7858-7868. https://doi.org/10.1021/acsnano.7b02211
Ashkenasy,
G., Hermans, T. M., Otto, S., & Taylor, A. F.
(2017). Systems chemistry. Chemical Society
Reviews, 46(9), 2543-2554. https://doi.org/10.1039/c7cs00117g
Duim,
H., & Otto, S. (2017). Towards
open-ended evolution in self-replicating molecular systems.
Beilstein Journal of Organic Chemistry,
13, 1189-1203. https://doi.org/10.3762/bjoc.13.118
2016
Sadownik,
J. W., Mattia, E., Nowak, P., & Otto, S. (2016).
Diversification of self-replicating molecules.
Nature Chemistry, 8(3), 264-269. https://doi.org/10.1038/nchem.2419
Mondal,
M., Radeva, N., Fanlo-Virgos, H., Otto, S., Klebe,
G., & Hirsch, A. K. H. (2016). Fragment
Linking and Optimization of Inhibitors of the Aspartic Protease
Endothiapepsin: Fragment-Based Drug Design Facilitated by Dynamic
Combinatorial Chemistry. Angewandte Chemie -
International Edition, 55(32), 9422-9426. https://doi.org/10.1002/anie.201603074
Nguyen,
V. D., Pal, A., Snijkers, F., Colomb-Delsuc, M., Leonetti,
G., Otto, S., & van der Gucht, J. (2016).
Multi-step control over self-assembled hydrogels of
peptide-derived building blocks and a polymeric
cross-linker. Soft Matter,
12(2), 432-440. https://doi.org/10.1039/c5sm02088c
2015
Li,
J., Nowak, P., & Otto, S. (2015). An
Allosteric Receptor by Simultaneous "Casting" and "Molding" in a
Dynamic Combinatorial Library. Angewandte Chemie -
International Edition, 54(3), 833-837. https://doi.org/10.1002/anie.201408907
Pal,
A., Malakoutikhah, M., Leonetti, G., Tezcan, M., Colomb-Delsuc, M.,
Nguyen, V. D., van der Gucht, J., & Otto, S.
(2015). Controlling the Structure and Length of
Self-Synthesizing Supramolecular Polymers through Nucleated Growth
and Disassembly. Angewandte Chemie - International
Edition, 54(27), 7852-7856. https://doi.org/10.1002/anie.201501965
Colomb-Delsuc,
M., Mattia, E., Sadownik, J. W., & Otto, S.
(2015). Exponential self-replication enabled through a fibre
elongation/breakage mechanism. Nature
Communications, 6, Article 7427. https://doi.org/10.1038/ncomms8427
Han,
Y., Nowak, P., Colomb-Delsuc, M., Leal, M. P., & Otto,
S. (2015). Instructable Nanoparticles Using Dynamic
Combinatorial Chemistry. Langmuir,
31(46), 12658-12663. https://doi.org/10.1021/acs.langmuir.5b03673
Nowak,
P., Saggiomo, V., Salehian, F., Colomb-Delsuc, M., Han, Y.,
& Otto, S. (2015). Localized Template-Driven
Functionalization of Nanoparticles by Dynamic Combinatorial
Chemistry. Angewandte Chemie - International
Edition, 54(14), 4192-4197. https://doi.org/10.1002/anie.201409667
Leonetti,
G., & Otto, S. (2015). Solvent Composition
Dictates Emergence in Dynamic Molecular Networks Containing
Competing Replicators. Journal of the American
Chemical Society, 137(5), 2067-2072. https://doi.org/10.1021/ja512644f
Mattia,
E., & Otto, S. (2015). Supramolecular
systems chemistry. Nature
Nanotechnology, 10(2), 111-119. https://doi.org/10.1038/nnano.2014.337
Nowak,
P., Colomb-Delsuc, M., Otto, S., & Li, J. (2015).
Template-Triggered Emergence of a Self-Replicator from a
Dynamic Combinatorial Library. Journal of the
American Chemical Society, 137(34),
10965-10969. https://doi.org/10.1021/jacs.5b04380
2014
Li,
J., Cvrtila, I., Colomb-Delsuc, M., Otten, E.,
& Otto, S. (2014). An "Ingredients" Approach to
Functional Self-Synthesizing Materials: A Metal-Ion-Selective,
Multi-Responsive, Self-Assembled Hydrogel.
Chemistry, 20(48), 15709-15714. https://doi.org/10.1002/chem.201404977
Li,
J., Nowak, P., & Otto, S. (2014). Catenanes
from catenanes: quantitative assessment of cooperativity in dynamic
combinatorial catenation. Chemical
Science, 5(12), 4968-4974. https://doi.org/10.1039/c4sc01998a
Grzybowski,
B., Otto, S., & Philp, D. (2014). Systems
chemistry: A web themed issue. Chemical
Communications, 50(95), 14924-14925. https://doi.org/10.1039/c4cc90422b
Fanlo-Virgos,
H., Alba, A.-N. R., Hamieh, S., Colomb-Delsuc, M., &
Otto, S. (2014). Transient Substrate-Induced Catalyst
Formation in a Dynamic Molecular Network.
Angewandte Chemie - International Edition,
53(42), 11346-11350. https://doi.org/10.1002/anie.201403480
2013
Hamieh,
S., Saggiomo, V., Nowak, P., Mattia, E., Ludlow, R. F., &
Otto, S. (2013). A "Dial-A-Receptor" Dynamic
Combinatorial Library. Angewandte
Chemie-International Edition, 52(47),
12368-12372. https://doi.org/10.1002/anie.201305744
Li,
J., Nowak, P., & Otto, S. (2013). Dynamic
Combinatorial Libraries: From Exploring Molecular Recognition to
Systems Chemistry. Journal of the American
Chemical Society, 135(25), 9222-9239. https://doi.org/10.1021/ja402586c
Rombouts,
W. H., Colomb-Delsuc, M., Werten, M. W. T., Otto, S.,
de Wolf, F. A., & van der Gucht, J. (2013). Enhanced
rigidity and rupture strength of composite hydrogel networks of
bio-inspired block copolymers. Soft
Matter, 9(29), 6936-6942. https://doi.org/10.1039/c3sm00091e
Saggiomo,
V., Hristova, Y. R., Ludlow, R. F., & Otto, S.
(2013). Systems chemistry: using thermodynamically controlled
networks to assess molecular similarity. Journal
of Systems Chemistry, 4(2). https://doi.org/10.1186/1759-2208-4-2
Otto,
S. (2013). The role of solvent cohesion in nonpolar
solvation. Chemical Science,
4(7), 2953-2959. https://doi.org/10.1039/c3sc50740h
Malakoutikhah,
M., Peyralans, J. J.-P., Colomb-Delsuc, M., Fanlo-Virgós,
H., Stuart, M. C. A., & Otto, S.
(2013). Uncovering the selection criteria for the emergence
of multi-building-block replicators from dynamic combinatorial
libraries. Journal of the American Chemical
Society, 135(49), 18406-18417. https://doi.org/10.1021/ja4067805
2012
Hamieh,
S., Ludlow, R. F., Perraud, O., West, K. R., Mattia, E.,
& Otto, S. (2012). A Synthetic Receptor for
Nicotine from a Dynamic Combinatorial Library.
Organic letters, 14(21), 5404-5407.
https://doi.org/10.1021/ol302260n
Otto,
S. (2012). Dynamic Molecular Networks: From Synthetic
Receptors to Self-Replicators. Accounts of
Chemical Research, 45(12), 2200-2210. https://doi.org/10.1021/ar200246j
Wang,
J., Stuart, M. A. C., Marcelis, A. T. M., Colomb-Delsuc, M.,
Otto, S., & van der Gucht, J. (2012). Stable
Polymer Micelles Formed by Metal Coordination.
Macromolecules, 45(17), 7179-7185.
https://doi.org/10.1021/ma301323z
Saggiomo,
V., Otto, S., Marques, I., Felix, V., Torroba, T.,
& Quesada, R. (2012). The role of lipophilicity in
transmembrane anion transport. Chemical
Communications, 48(43), 5274-5276. https://doi.org/10.1039/c2cc31825c
2011
Rodriguez-Docampo,
Z., Eugenieva-Ilieva, E., Reyheller, C., Belenguer, A. M., Kubik,
S., & Otto, S. (2011). Dynamic combinatorial
development of a neutral synthetic receptor that binds sulfate with
nanomolar affinity in aqueous solution. Chemical
Communications, 47(35), 9798-9800. https://doi.org/10.1039/c1cc13451e
Hunt,
R. A. R., Otto, S., & Hunt, R. A. R. (2011).
Dynamic combinatorial libraries: new opportunities in systems
chemistry. Chemical Communications,
47(3), 847-858. https://doi.org/10.1039/c0cc03759a
Li,
J., Carnall, J. M. A., Stuart, M. C. A., &
Otto, S. (2011). Hydrogel Formation upon Photoinduced
Covalent Capture of Macrocycle Stacks from Dynamic Combinatorial
Libraries. Angewandte Chemie - International
Edition, 50(36), 8384-8386. https://doi.org/10.1002/anie.201103297
2010
Besenius,
P., Cormack, P. A. G., Ludlow, R. F., Otto, S., &
Sherrington, D. C. (2010). Affinity chromatography in dynamic
combinatorial libraries: one-pot amplification and isolation of a
strongly binding receptor. Organic &
Biomolecular Chemistry, 8(10), 2414-2418. https://doi.org/10.1039/c000333f
Reek,
J. N. H., & Otto, S. (2010). Dynamic
Combinatorial Chemistry. Wiley. https://doi.org/10.1002/9783527629701
Mansfeld,
F. M., Au-Yeung, H. Y., Sanders, J. K. M., & Otto,
S. (2010). Dynamic combinatorial chemistry at the
phospholipid bilayer interface. Journal of Systems
Chemistry, 1(12). https://doi.org/10.1186/1759-2208-1-12
Au-Yeung,
H. Y., Cougnon, F. B. L., Otto, S., Pantos, G. D.,
Sanders, J. K. M., & Pantoş, G. D. (2010).
Exploiting donor-acceptor interactions in aqueous dynamic
combinatorial libraries: exploratory studies of simple
systems. Chemical Science,
1(5), 567-574. https://doi.org/10.1039/c0sc00307g
Carnall,
J. M. A., Waudby, C. A., Belenguer, A. M., Stuart, M. C.
A., Peyralans, J. J. .-P., & Otto, S.
(2010). Mechanosensitive Self-Replication Driven by
Self-Organization. Science,
327(5972), 1502-1506. https://doi.org/10.1126/science.1182767
Otto,
S. (2010). MOLECULAR MACHINES Tiny steps: Tiny
steps. Nature Chemistry,
2(2), 75-76. https://doi.org/10.1038/nchem.525
Ludlow,
R. F., & Otto, S. (2010). The Impact of the
Size of Dynamic Combinatorial Libraries on the Detectability of
Molecular Recognition Induced Amplification.
Journal of the American Chemical Society,
132(17), 5984-+. https://doi.org/10.1021/ja1013689
Otto,
S. (2010). The Practice of Dynamic Combinatorial
Libraries: Analytical Chemistry, Experimental Design, and Data
Analysis. In S. Otto, & J. N. H. Reek (Eds.),
Dynamic Combinatorial Chemistry (pp. 23-47).
Otto,
S., & Reek, J. N. H. (2010). Trends and
Perspectives. In S. Otto, & J. N. H. Reek (Eds.),
Dynamic Combinatorial Chemistry (pp. 185-194).
Kiedrowski,
G. V., Otto, S., & Herdewijn, P. (2010).
Welcome Home, Systems Chemists! Journal of
Systems Chemistry, 1(1). https://doi.org/10.1186/1759-2208-1-1
2009
Likhitsup,
A., Deeth, R. J., Otto, S., & Marsh, A. (2009).
Apparent non-statistical binding in a ditopic receptor for
guanosine. Organic and Biomolecular
Chemistry, 7(10), 2093-2103. https://doi.org/10.1039/b812969j
Hunt,
R. A. R., Ludlow, R. F., & Otto, S. (2009).
Estimating equilibrium constants for aggregation from the
product distribution of a dynamic combinatorial library.
Organic letters, 11(22), 5110-5113.
https://doi.org/10.1021/ol901656x
Otto,
S. (2009). MOLECULAR SELF-ASSEMBLY Helping
themselves. Nature Nanotechnology,
4(1), 13-14. https://doi.org/10.1038/nnano.2008.387
Mansfeld,
F. M., Feng, G., & Otto, S. (2009).
Photo-induced molecular-recognition-mediated adhesion of
giant vesicles. Organic and Biomolecular
Chemistry, 7(20), 4289-4295. https://doi.org/10.1039/b910197g
Peyralans,
J. J. P., & Otto, S. (2009). Recent
highlights in systems chemistry. Current Opinion
in Chemical Biology, 13(5-6), 705-713. https://doi.org/10.1016/j.cbpa.2009.08.006
Au-Yeung,
H. Y., Pengo, P., Pantoş, G. D., Otto, S., &
Sanders, J. K. M. (2009). Templated amplification of a
naphthalenediimide-based receptor from a donor–acceptor
dynamic combinatorial library in water. Chemical
Communications, 419-421. https://doi.org/10.1039/b816979a
2008
West,
K. R., Ludlow, R. F., Corbett, P. T., Besenius, P., Mansfeld, F.
M., Cormack, P. A. G., Sherrington, D. C., Goodman, J. M.,
Stuart, M. C. A., & Otto, S. (2008).
Dynamic combinatorial discovery of a [2]-catenane and its
guest-induced conversion into a molecular square host.
Journal of the American Chemical Society,
130(33), 10834-+. https://doi.org/10.1021/ja801508q
Corbett,
P. T., Sanders, J. K. M., & Otto, S. (2008).
Exploring the Relation between Amplification and Binding in
Dynamic Combinatorial Libraries of Macrocyclic Synthetic Receptors
in Water. Chemistry, 14(7).
https://doi.org/10.1002/chem.200701413
Rodriguez-Docampo,
Z., & Otto, S. (2008). Orthogonal or
simultaneous use of disulfide and hydrazone exchange in dynamic
covalent chemistry in aqueous solution. Chemical
Communications, 41(42), 5301-5303. https://doi.org/10.1039/b808725c
Besenius,
P., Cormack, P. A. G., Ludlow, R. F., Otto, S., &
Sherrington, D. C. (2008). Polymer-supported cationic
templates for molecular recognition of anionic hosts in
water. Chemical Communications,
2(24). https://doi.org/10.1039/b802982b
Ludlow,
R. F., & Otto, S. (2008). Systems
chemistry. Chemical Society Reviews,
37(1), 101-108. https://doi.org/10.1039/b611921m
Besenius,
P., Cormack, P. A. G., Liu, J., Otto, S., Sanders, J.
K. M., & Sherrington, D. C. (2008). Tailored
Polymer-Supported Templates in Dynamic Combinatorial Libraries:
Simultaneous Selection, Amplification and Isolation of Synthetic
Receptors. Chemistry, 14(29).
https://doi.org/10.1002/chem.200800326
Ludlow,
R. F., & Otto, S. (2008). Two-vial, LC-MS
identification of ephedrine receptors from a solution-phase dynamic
combinatorial library of over 9000 components.
Journal of the American Chemical Society,
130(37), 12218-+. https://doi.org/10.1021/ja803317k
2007
Sarma,
R. J., Otto, S., & Nitschke, J. R. (2007).
Disulfides, Imines, and Metal Coordination within a Single
System: Interplay between Three Dynamic Equilibria.
Chemistry, 13(34). https://doi.org/10.1002/chem.200701228
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