Skip to ContentSkip to Navigation
About us Latest news Press information

Sommer, Prof. Iris

Iris Sommer
Iris Sommer

Iris Sommer is Professor of Psychiatry at the University Medical Center Groningen. She is an international expert in neuropsychiatry. Her research addresses the origins of psychiatric disorders and the development of innovative treatments. Sommer trained as a physician and psychiatrist, obtained her PhD cum laude in the field of schizophrenia, and founded the Stemmenpoli (Voices Clinic) at the UMC Utrecht. In 2017, her research on hallucinations ‘Zie ik spoken’ [Do I see ghosts?], was voted public research of the year.

Iris Sommer's pioneering work focuses, among other things, on the surprising fact that the female brain is much less well studied than the male brain. One of Sommer's key findings is that female hormones (such as estrogens) play a major protective role in psychotic disorders. While commonly prescribed antipsychotics actually appear to suppress the production of estrogens.

Current psychiatric treatments are mostly based on clinical studies in which women are underrepresented. This results in treatment for women being less evidence-based than for men, the consequences of which are significant. For instance, diagnoses in women are more delayed, and sometimes missed altogether. Furthermore, treatments are not as suitable, making women more likely to overdose and therefore have side effects. And menopause is not taken into account either.

Sommer wrote several books, including Haperende Hersenen [Faltering brains] and De Zeven Zintuigen [The seven senses]. The book is about how we perceive the world only partly with our senses and supplement the rest from our background. With BNR Nieuwsradio, Sommer recorded five podcasts, covering various topics related to the brain.

Previously in the news

Dr Iris Sommer at the University of the Netherlands:

Contact and further information

Publications

2025

Solmi, M., Thompson, T., Cortese, S., Estradé, A., Agorastos, A., Radua, J., Dragioti, E., Vancampfort, D., Thygesen, L. C., Aschauer, H., Schlögelhofer, M., Aschauer, E., Schneeberger, A., Huber, C. G., Hasler, G., Conus, P., Cuénod, K. Q. D., von Känel, R., Arrondo, G., ... Sommer, I. (2025). Collaborative outcomes study on health and functioning during infection times (COH-FIT): Insights on modifiable and non-modifiable risk and protective factors for wellbeing and mental health during the COVID-19 pandemic from multivariable and network analyses. European Neuropsychopharmacology, 90, 1-15. https://doi.org/10.1016/j.euroneuro.2024.07.010

2024

TAPER international research consortium, Koops, S., Allott, K., De Haan, L., Chen, E., Hui, C., Killackey, E., Long, M., Moncrieff, J., Sommer, I., Stürup, A. E., Wunderink, L., & Begemann, M. (2024). Addressing the Evidence to Practice Gap: What to Expect from International Antipsychotic Dose Reduction Studies in the Tapering Anti-Psychotics and Evaluating Recovery Consortium. Schizophrenia Bulletin, 50(1), 5-8. https://doi.org/10.1093/schbul/sbad112
King, B., Kempton, M. J., Broberg, B. V., Merritt, K., Barker, G. J., Lythgoe, D. J., Perez-Iglesias, R., Baandrup, L., Düring, S. W., Stone, J. M., Rostrup, E., Sommer, I. E., Glenthøj, B., Kahn, R. S., Dazzan, P., McGuire, P. K., & Egerton, A. (2024). A letter to the editor: The effects of alcohol use on brain glutamate in first episode psychosis. Schizophrenia Research, 266, 234-236. https://doi.org/10.1016/j.schres.2024.02.013
van Zonneveld, S. M., van den Oever, E. J., Haarman, B. C. M., Grandjean, E. L., Nuninga, J. O., van de Rest, O., & Sommer, I. E. C. (2024). An Anti-Inflammatory Diet and Its Potential Benefit for Individuals with Mental Disorders and Neurodegenerative Diseases—A Narrative Review. Nutrients, 16(16), Article 2646. https://doi.org/10.3390/nu16162646
de Haan, L., Gangadin, S. S., de Beer, F., Djordjevic, M., Begemann, M. J. H., & Sommer, I. E. C. (2024). Antipsychotica na een eerste psychose. Nederlands Tijdschrift voor Geneeskunde, 168, Article D7594. https://www.ntvg.nl/artikelen/antipsychotica-na-een-eerste-psychose
HAMLETT OPHELIA Consortium, de Beer, F., Wijnen, B., Wouda, L., Koops, S., Gangadin, S., Veling, W., van Beveren, N., de Haan, L., Begemann, M. J. H., Sommer, I. E. C., & Djordjevic, M. (2024). Antipsychotic dopamine D2 affinity and negative symptoms in remitted first episode psychosis patients. Schizophrenia Research, 274, 299-306. https://doi.org/10.1016/j.schres.2024.09.030
Brand, B. A., de Boer, J. N., Willemse, E. J. M., Weickert, C. S., Sommer, I. E., & Weickert, T. W. (Accepted/In press). Antipsychotic-induced prolactin elevation in premenopausal women with schizophrenia: associations with estrogen, disease severity and cognition. Archives of Women's Mental Health. https://doi.org/10.1007/s00737-024-01491-9
d'Angremont, E., van der Zee, S., Slingerland, S., Slomp, A. C., de Vries, E. F. J., van Laar, T., & Sommer, I. E. (2024). Cholinergic deficiency in Parkinson's disease patients with visual hallucinations. Brain : a Journal of Neurology, 147(10), 3370–3378. https://doi.org/10.1093/brain/awae186
Marschall, T. M., Brederoo, S. G., Koops, S., Ćurčić-Blake, B., & Sommer, I. E. C. (2024). Content-based clustering of hallucinations across sensory modalities in a large online survey. Scientific Reports, 14, Article 23108. https://doi.org/10.1038/s41598-024-69798-2
Brand, B. A., Willemse, E. J. M., Hamers, I. M. H., & Sommer, I. E. (2024). Correction to: Evidence-Based Recommendations for the Pharmacological Treatment of Women with Schizophrenia Spectrum Disorders (Current Psychiatry Reports, (2023), 25, 11, (723-733), 10.1007/s11920-023-01460-6). Current Psychiatry Reports, 26(10), 550-551. https://doi.org/10.1007/s11920-024-01520-5
Zaki, J. K., Lago, S. G., Spadaro, B., Rustogi, N., Gangadin, S. S., Benacek, J., Drexhage, H. A., de Witte, L. D., Kahn, R. S., Sommer, I. E. C., Bahn, S., & Tomasik, J. (2024). Exploring peripheral biomarkers of response to simvastatin supplementation in schizophrenia. Schizophrenia Research, 266, 66-74. https://doi.org/10.1016/j.schres.2024.02.011
Solmi, M., Thompson, T., Estradé, A., Agorastos, A., Radua, J., Cortese, S., Dragioti, E., Vancampfort, D., Thygesen, L. C., Aschauer, H., Schlögelhofer, M., Aschauer, E., Schneeberger, A., Huber, C. G., Hasler, G., Conus, P., Cuénod, K. Q. D., von Känel, R., Arrondo, G., ... Correll, C. U. (2024). Global and risk-group stratified well-being and mental health during the COVID-19 pandemic in adults: Results from the international COH-FIT Study. Psychiatry Research, 342, Article 115972. https://doi.org/10.1016/j.psychres.2024.115972
Gangadin, S. S., Enthoven, A. D., van Beveren, N. J. M., Laman, J. D., & Sommer, I. E. C. (2024). Immune Dysfunction in Schizophrenia Spectrum Disorders. Annual review of clinical psychology, 20(1), 229-257. https://doi.org/10.1146/annurev-clinpsy-081122-013201
Li, Y., Yolland, C. O. B., Rossell, S. L., Sommer, I. E. C., & Toh, W. L. (2024). Multisensory hallucinations and other unusual sensory experiences in the context of migraine: a systematic review. Journal of Neurology, 271, 1717–1746. https://doi.org/10.1007/s00415-023-12144-9
Borkent, J., Ioannou, M., Neijzen, D., Haarman, B. C. M., & Sommer, I. E. C. (2024). Probiotic Formulation for Patients With Bipolar or Schizophrenia Spectrum Disorder: A Double-Blind, Randomized Placebo-Controlled Trial. Schizophrenia Bulletin, Article sbae188. Advance online publication. https://doi.org/10.1093/schbul/sbae188
HAMLETT OPHELIA Consortium, de Beer, F., Koops, S., Schoevers, R. A., Veling, W., van Beveren, N., de Haan, L., & Boonstra, N. (2024). Psychiatrists effect on positive symptom severity and daily functioning during pharmacotherapy for first-episode psychosis patients. Scientific Reports, 14(1), Article 22871. https://doi.org/10.1038/s41598-024-72678-4
van Opstal, D. P. J., Kia, S. M., Jakob, L., Somers, M., Sommer, I. E. C., Winter-van Rossum, I., Kahn, R. S., Cahn, W., & Schnack, H. G. (2024). Psychosis Prognosis Predictor: A continuous and uncertainty-aware prediction of treatment outcome in first-episode psychosis. Acta Psychiatrica Scandinavica. Advance online publication. https://doi.org/10.1111/acps.13754
Brand, B. A., Sommer, I. E., Gangadin, S. S., Tanskanen, A., Tiihonen, J., & Taipale, H. (2024). Real-World Effectiveness of Menopausal Hormone Therapy in Preventing Relapse in Women With Schizophrenia or Schizoaffective Disorder. The American journal of psychiatry, 181(10), 893-900. https://doi.org/10.1176/appi.ajp.20230850
Ioannou, M., Borkent, J., Andreu-Sánchez, S., Wu, J., Fu, J., Sommer, I. E. C., & Haarman, B. C. M. (2024). Reproducible gut microbial signatures in bipolar and schizophrenia spectrum disorders: A metagenome-wide study. Brain, Behavior, and Immunity, 121, 165-175. https://doi.org/10.1016/j.bbi.2024.07.009
Sommer, I. E., Brand, B. A., Stuijt, C. C. M., & Touw, D. J. (2024). Sex differences need to be considered when treating women with psychotropic drugs. World psychiatry, 23(1), 151-152. https://doi.org/10.1002/wps.21155
De jager, J. E., Boesjes, R., Roelandt, G. H. J., Koliaki, I., Sommer, I. E. C., Schoevers, R. A., & Nuninga, J. O. (2024). Shared effects of electroconvulsive shocks and ketamine on neuroplasticity: A Systematic Review of Animal Models of Depression. Neuroscience & Biobehavioral Reviews, 164, Article 105796. https://doi.org/10.1016/j.neubiorev.2024.105796
d'Angremont, E., Sommer, I. E. C., van der Zee, S., van Laar, T., de Vries, E. F. J., & Zijdewind, I. (2024). Short-latency afferent inhibition as a biomarker of cholinergic degeneration compared to PET imaging in Parkinson's disease. Parkinsonism & Related Disorders, 121, Article 106032. https://doi.org/10.1016/j.parkreldis.2024.106032
Hamers, I. M. H., Brand, B. A., Begemann, M. J. H., Weickert, C. S., Weickert, T. W., & Sommer, I. E. C. (2024). The association of prolactin and gonadal hormones with cognition and symptoms in men with schizophrenia spectrum disorder: Divergent effects of testosterone and estrogen. Schizophrenia Research, 270, 273-280. https://doi.org/10.1016/j.schres.2024.06.022
Brederoo, S. G., Alderson-Day, B., de Boer, J. N., Linszen, M. M. J., & Sommer, I. E. C. (2024). The experience of felt presence in a general population sample. British Journal of Psychiatry, 224(4), 119-121. https://doi.org/10.1192/bjp.2024.7
Khaled, S. M., Brederoo, S. G., Alabdulla, M., Sommer, I. E. C., & Woodruff, P. W. (2024). The role of religiosity types in the phenomenology of hallucinations: A large cross-sectional community-based study in a predominantly Muslim society. Schizophrenia Research, 265, 30-38. https://doi.org/10.1016/j.schres.2022.11.003

2023

Toh, W. L., Yolland, C. O., Li, Y., Sommer, I. E., & Rossell, S. (2024). Multisensory Hallucinatory Experiences in Migraine: A Preliminary Basis for Olfactory, Somatic-Tactile, and Gustatory Auras. Neurology: Clinical Practice, 14(1), Article e200217. https://doi.org/10.1212/CPJ.0000000000200217
van der Heijden-Hobus, I. M. W., Rosema, B. S., Vorstman, J. A. S., Kas, M. J. H., Franke, S. K., Boonstra, N., & Sommer, I. E. C. (2024). Personal preferences for treatment and care during and after a First Episode Psychosis: A qualitative study. Early intervention in psychiatry, 18(6), 415-424. https://doi.org/10.1111/eip.13477
Fond, G., Mallet, J., Urbach, M., Benros, M. E., Berk, M., Billeci, M., Boyer, L., Correll, C. U., Fornaro, M., Kulkarni, J., Leboyer, M., Llorca, P. M., Misdrahi, D., Rey, R., Schürhoff, F., Solmi, M., Sommer, I. E. C., Stahl, S. M., Pignon, B., & Berna, F. (2023). Adjunctive agents to antipsychotics in schizophrenia: A systematic umbrella review and recommendations for amino acids, hormonal therapies and anti-inflammatory drugs. BMJ mental health, 26(1), Article e300771. https://doi.org/10.1136/bmjment-2023-300771
Aleman, A., & Sommer, I. E. C. (2023). Advances in Hallucination Research. Schizophrenia Bulletin, 49(1), S1-S2. https://doi.org/10.1093/schbul/sbac210
Luykx, J. J., Gonzalez-Diaz, J. M., Guu, T. W., van der Horst, M. Z., van Dellen, E., Boks, M. P., Guloksuz, S., DeLisi, L. E., Sommer, I. E., Cummins, R., Shiers, D., Lee, J., Every-Palmer, S., Mhalla, A., Chadly, Z., Chan, S. K. W., Cotes, R. O., Takahashi, S., Benros, M. E., ... Tiihonen, J. (2023). An international research agenda for clozapine-resistant schizophrenia. The Lancet Psychiatry, 10(8), 644-652. https://doi.org/10.1016/S2215-0366(23)00109-8
Brand, B. A., Haveman, Y. R. A., de Beer, F., de Boer, J. N., Dazzan, P., & Sommer, I. E. C. (2023). Antipsychotic medication for women with schizophrenia spectrum disorders: CORRIGENDUM. Psychological Medicine, 53(10), 4832. https://doi.org/10.1017/S0033291723001344
Scheurink, T. A. W., Borkent, J., Gangadin, S. S., El Aidy, S., Mandl, R., & Sommer, I. E. C. (2023). Association between gut permeability, brain volume, and cognition in healthy participants and patients with schizophrenia spectrum disorder. Brain and Behavior, 13(6), Article e3011. https://doi.org/10.1002/brb3.3011
Van der A, J., De Jager, J. E., van Dellen, E., Mandl, R. C. W., Somers, M., Boks, M. P. M., Sommer, I. E. C., & Nuninga, J. O. (2023). Changes in perfusion, and structure of hippocampal subfields related to cognitive impairment after ECT: A pilot study using ultra high field MRI. Journal of Affective Disorders, 325, 321-328. https://doi.org/10.1016/j.jad.2023.01.016
D'Angremont, E., Begemann, M. J. H., Van Laar, T., & Sommer, I. E. C. (2023). Cholinesterase Inhibitors for Treatment of Psychotic Symptoms in Alzheimer Disease and Parkinson Disease: A Meta-analysis. Jama neurology, 80(8), 813-823. https://doi.org/10.1001/jamaneurol.2023.1835
Kruiper, C., Sommer, I. E. C., Koster, M., Bakker, P. R., Durston, S., & Oranje, B. (2023). Clonidine augmentation in patients with schizophrenia: A double-blind, randomized placebo-controlled trial. Schizophrenia Research, 255, 148-154. https://doi.org/10.1016/j.schres.2023.03.039
Ciampelli, S., Voppel, A. E., de Boer, J. N., Koops, S., & Sommer, I. E. C. (2023). Combining automatic speech recognition with semantic natural language processing in schizophrenia. Psychiatry Research, 325, Article 115252. https://doi.org/10.1016/j.psychres.2023.115252
Gangadin, S. S., Germann, M., de Witte, L. D., Gelderman, K. A., Mandl, R. C. W., & Sommer, I. E. C. (2023). Complement component 4A protein levels are negatively related to frontal volumes in patients with schizophrenia spectrum disorders. Schizophrenia Research, 261, 6-14. https://doi.org/10.1016/j.schres.2023.08.031
Khaled, S. M., Brederoo, S. G., Yehya, A., Alabdulla, M., Woodruff, P. W., & Sommer, I. E. C. (2023). Cross-cultural Differences in Hallucinations: A Comparison Between Middle Eastern and European Community-Based Samples. Schizophrenia Bulletin, 49(1), S13-S24. https://doi.org/10.1093/schbul/sbac086
Brand, B. A., Willemse, E. J. M., Hamers, I. M. H., & Sommer, I. E. (2023). Evidence-Based Recommendations for the Pharmacological Treatment of Women with Schizophrenia Spectrum Disorders. Current Psychiatry Reports, 25(11), 723-733. https://doi.org/10.1007/s11920-023-01460-6
Kübler, R., Ormel, P. R., Sommer, I. E. C., Kahn, R. S., & de Witte, L. D. (2023). Gene expression profiling of monocytes in recent-onset schizophrenia. Brain, Behavior, and Immunity, 111, 334-342. https://doi.org/10.1016/j.bbi.2023.04.019
Marschall, T. M., van Dijk, P., Kluk, K., Koops, S., Linszen, M. M. J., Griffiths, T. D., Toh, W. L., Malicka, A. N., Kovačić, D., Mulert, C., Sommer, I. E. C., & Ćurčić-Blake, B. (2023). Hallucinations in Hearing Impairment: How Informed Are Clinicians? Schizophrenia Bulletin, 49(S1), S33–S40. https://doi.org/10.1093/schbul/sbac034
Koops, S., Brederoo, S. G., Voppel, A. E., & Sommer, I. E. C. (2023). Herkennen van depressie met computationele taalanalyse. Tijdschrift voor Psychiatrie, 65(3), 198-201. https://www.tijdschriftvoorpsychiatrie.nl/nl/artikelen/article/50-13129_Herkennen-van-depressie-met-computationele-taalanalyse
van den Heuvel, M. P., Ardesch, D. J., Scholtens, L. H., de Lange, S. C., van Haren, N. E. M., Sommer, I. E. C., Dannlowski, U., Repple, J., Preuss, T. M., Hopkins, W. D., & Rilling, J. K. (2023). Human and chimpanzee shared and divergent neurobiological systems for general and specific cognitive brain functions. Proceedings of the National Academy of Sciences of the United States of America, 120(22), Article e2218565120. https://doi.org/10.1073/pnas.2218565120
Tan, E. J., Sommer, I. E. C., & Palaniyappan, L. (2023). Language and Psychosis: Tightening the Association. Schizophrenia Bulletin, 49(2), S83-S85. https://doi.org/10.1093/schbul/sbac211
So, S. H. W., Chau, A. K. C., Chung, L. K. H., Leung, C. M., Chong, G. H. C., Chang, W. C., Mak, A. D. P., Chan, S. S. M., Lee, S., & Sommer, I. E. (2023). Moment-To-moment affective dynamics in schizophrenia and bipolar disorder. European Psychiatry, 66(1), Article e67. https://doi.org/10.1192/j.eurpsy.2023.2438
Corona Hernández, H., Corcoran, C., Achim, A. M., de Boer, J. N., Boerma, T., Brederoo, S. G., Cecchi, G. A., Ciampelli, S., Elvevåg, B., Fusaroli, R., Giordano, S., Hauglid, M., van Hessen, A., Hinzen, W., Homan, P., de Kloet, S. F., Koops, S., Kuperberg, G. R., Maheshwari, K., ... Palaniyappan, L. (2023). Natural Language Processing Markers for Psychosis and Other Psychiatric Disorders: Emerging Themes and Research Agenda From a Cross-Linguistic Workshop. Schizophrenia Bulletin, 49(2), S86-S92. https://doi.org/10.1093/schbul/sbac215
Jairaj, C., Seneviratne, G., Bergink, V., Sommer, I. E., & Dazzan, P. (2023). Postpartum psychosis: A proposed treatment algorithm. Journal of Psychopharmacology, 37(10), 960-970. https://doi.org/10.1177/02698811231181573
van der Weijden-Germann, M., Brederoo, S. G., Linszen, M. M. J., & Sommer, I. E. C. (2023). Recreational Drug Use and Distress From Hallucinations in the General Dutch Population. Schizophrenia Bulletin, 49(1), S41-S47. https://doi.org/10.1093/schbul/sbac190
Borkent, J., Ioannou, M., Folkertsma, T., Wardenaar, K. J., Haarman, B. C. M., van Goor, H., Sommer, I. E. C., & Bourgonje, A. R. (2023). Serum free thiols in recently diagnosed patients with schizophrenia spectrum disorder: a potentially useful biomarker of oxidative stress. Psychiatry Research, 321, Article 115075. https://doi.org/10.1016/j.psychres.2023.115075
Brederoo, S. G., de Boer, J. N., Linszen, M. M. J., Blom, R. E., Begemann, M. J. H., & Sommer, I. E. C. (2023). Social Deafferentation and the Relation Between Loneliness and Hallucinations. Schizophrenia Bulletin, 49(1), S25-S32. https://doi.org/10.1093/schbul/sbac064
Ciampelli, S., de Boer, J. N., Voppel, A. E., Corona Hernandez, H., Brederoo, S. G., van Dellen, E., Mota, N. B., & Sommer, I. E. C. (2023). Syntactic Network Analysis in Schizophrenia-Spectrum Disorders. Schizophrenia Bulletin, 49(2), S172-S182. https://doi.org/10.1093/schbul/sbac194
Yehya, A., Khaled, S. M., Sommer, I. E. C., Elhag, S. F., Hassan, M. H. M. O., Woodruff, P., & Alabdalla, M. (2023). The Arabic Questionnaire for Psychotic Experiences in patients with psychotic disorders: a clinical validation. BMC Psychiatry, 23(1), Article 141. https://doi.org/10.1186/s12888-023-04649-4
HAMLETT and OPHELIA Consortium, Enthoven, A.-S. D., Gangadin, S. S., de Haan, L., Veling, W., de Vries, E. F. J., Doorduin, J., Begemann, M. J. H., & Sommer, I. E. C. (2023). The association of childhood trauma with depressive and negative symptoms in recent onset psychosis: a sex-specific analysis. Psychological Medicine, 53, 7795–7804. https://doi.org/10.1017/S0033291723001824
Brand, B. A., de Boer, J. N., Marcelis, M. C., Grootens, K. P., Luykx, J. J., & Sommer, I. E. (2023). The Direct and Long-Term Effects of Raloxifene as Adjunctive Treatment for Schizophrenia-Spectrum Disorders: A Double-Blind, Randomized Clinical Trial. Schizophrenia Bulletin, 49(6), 1579-1590. https://doi.org/10.1093/schbul/sbad058
Jeuring, H. W., D'Angremont, E., Tol, J. M. H., Risselada, A. J., Sommer, I. E. C., & Oude Voshaar, R. C. (2023). The effectiveness of off-label dopamine stimulating agents in depressive disorder: A systematic review and meta-analysis. Psychiatry Research, 319, Article 115010. https://doi.org/10.1016/j.psychres.2022.115010
Marschall, T. M., Koops, S., Brederoo, S. G., Cabral, J., Ćurčić-Blake, B., & Sommer, I. E. C. (2023). Time varying dynamics of hallucinations in clinical and non-clinical voice-hearers. NeuroImage: Clinical, 37, Article 103351. https://doi.org/10.1016/j.nicl.2023.103351
Solmi, M., Thompson, T., Estradé, A., Agorastos, A., Radua, J., Cortese, S., Dragioti, E., Leisch, F., Vancampfort, D., Thygesen, L. C., Aschauer, H., Schlögelhofer, M., Aschauer, E., Schneeberger, A., Huber, C. G., Hasler, G., Conus, P., Do Cuénod, K. Q., von Känel, R., ... Correll, C. U. (2023). Validation of the Collaborative Outcomes study on Health and Functioning during Infection Times (COH-FIT) questionnaire for adults. Journal of Affective Disorders, 326, 249-261. https://doi.org/10.1016/j.jad.2022.12.022

2022

Gangadin, S. S., Mandl, R. C. W., de Witte, L. D., van Haren, N. E. M., Schutte, M. J. L., Begemann, M. J. H., Kahn, R. S., & Sommer, I. E. C. (2024). Lower fractional anisotropy without evidence for neuro-inflammation in patients with early-phase schizophrenia spectrum disorders. Schizophrenia Research, 264, 557-566. https://doi.org/10.1016/j.schres.2022.12.009
Corona Hernández, H., de Boer, J., Brederoo, S., Voppel, A., & Sommer, I. E. C. (2023). Assessing coherence through linguistic connectives: Analysis of speech in patients with schizophrenia-spectrum disorders. Schizophrenia Research, 259, 48-58. https://doi.org/10.1016/j.schres.2022.06.013
Hugdahl, K., Craven, A. R., Johnsen, E., Ersland, L., Stoyanov, D., Kandilarova, S., Sandoy, L. B., Kroken, R. A., Loberg, E.-M., & Sommer, I. E. (2023). Neural Activation in the Ventromedial Prefrontal Cortex Precedes Conscious Experience of Being in or Out of a Transient Hallucinatory State. Schizophrenia Bulletin, 49(1), S58–S67. https://doi.org/10.1093/schbul/sbac028
Voppel, A. E., de Boer, J. N., Brederoo, S. G., Schnack, H. G., & Sommer, I. E. C. (2023). Semantic and Acoustic Markers in Schizophrenia-Spectrum Disorders: A Combinatory Machine Learning Approach. Schizophrenia Bulletin, 49(2), S163-S171. https://doi.org/10.1093/schbul/sbac142
Sommer, I. E., Brand, B. A., Gangadin, S., Tanskanen, A., Tiihonen, J., & Taipale, H. (2023). Women with Schizophrenia-Spectrum Disorders After Menopause: A Vulnerable Group for Relapse. Schizophrenia Bulletin, 49(1), 136–143. https://doi.org/10.1093/schbul/sbac139
Corona Hernández, H., Brederoo, S., de Boer, J., & Sommer, I. E. C. (2022). A data-driven linguistic characterization of hallucinated voices in clinical and non-clinical voice-hearers. Schizophrenia Research, 241, 210-217. https://doi.org/10.1016/j.schres.2022.01.055
Grandjean, E. L., van Zonneveld, S. M., Sommer, I. E. C., & Haarman, B. C. M. (2022). Anti-inflammatory dietary patterns to treat bipolar disorder? Journal of Affective Disorders, 311, 254-255. https://doi.org/10.1016/j.jad.2022.05.073
Sommer, I. E. C., Horowitz, M., Allott, K., Speyer, H., & Begemann, M. J. H. (2022). Antipsychotic maintenance treatment versus dose reduction: how the story continues. The Lancet Psychiatry, 9(8), 602-603. https://doi.org/10.1016/S2215-0366(22)00230-9
Brand, B. A., Haveman, Y. R. A., De Beer, F., De Boer, J. N., Dazzan, P., & Sommer, I. E. C. (2022). Antipsychotic medication for women with schizophrenia spectrum disorders. Psychological Medicine, 52(4), 649 - 663. https://doi.org/10.1017/S0033291721004591
Eltokhi, A., & Sommer, I. E. (2022). A Reciprocal Link Between Gut Microbiota, Inflammation and Depression: A Place for Probiotics? Frontiers in Neuroscience, 16, Article 852506. https://doi.org/10.3389/fnins.2022.852506
de Rijke, T. J., Doting, M. H. E., van Hemert, S., De Deyn, P. P., van Munster, B. C., Harmsen, H. J. M., & Sommer, I. E. C. (2022). A Systematic Review on the Effects of Different Types of Probiotics in Animal Alzheimer's Disease Studies. Frontiers in Psychiatry, 13, Article 879491. https://doi.org/10.3389/fpsyt.2022.879491
Puvogel, S., Palma, V., & Sommer, I. E. C. (2022). Brain vasculature disturbance in schizophrenia. Current opinion in psychiatry, 35(3), 146-156. https://doi.org/10.1097/YCO.0000000000000789
Oomen, P. P., de Boer, J. N., Brederoo, S. G., Voppel, A. E., Brand, B. A., Wijnen, F. N. K., & Sommer, I. E. C. (2022). Characterizing speech heterogeneity in schizophrenia-spectrum disorders. Journal of psychopathology and clinical science, 131(2), 172-181. https://doi.org/10.1037/abn0000736
Zaki, J. K., Lago, S. G., Rustogi, N., Gangadin, S. S., Benacek, J., van Rees, G. F., Haenisch, F., Broek, J. A., Suarez-Pinilla, P., Ruland, T., Auyeung, B., Mikova, O., Kabacs, N., Arolt, V., Baron-Cohen, S., Crespo-Facorro, B., Drexhage, H. A., de Witte, L. D., Kahn, R. S., ... Tomasik, J. (2022). Diagnostic model development for schizophrenia based on peripheral blood mononuclear cell subtype-specific expression of metabolic markers. Translational Psychiatry, 12, Article 457. https://doi.org/10.1038/s41398-022-02229-w
Adam, O., Blay, M., Brunoni, A. R., Chang, H.-A., Gomes, J. S., Javitt, D. C., Jung, D.-U., Kantrowitz, J. T., Koops, S., Lindenmayer, J.-P., Palm, U., Smith, R. C., Sommer, I. E., Lane Valiengo, L. D. C., Weickert, T. W., Brunelin, J., & Mondino, M. (2022). Efficacy of Transcranial Direct Current Stimulation to Improve Insight in Patients With Schizophrenia: A Systematic Review and Meta-analysis of Randomized Controlled Trials. Schizophrenia Bulletin, 48(6), 1284–1294. https://doi.org/10.1093/schbul/sbac078
Sommer, I. E., & N de Boer, J. (2022). How to reap the benefits of language for psychiatry. Psychiatry Research, 318, Article 114932. https://doi.org/10.1016/j.psychres.2022.114932
Aichholzer, M., Gangadin, S. S., Sommer, I. E. C., Wijkhuis, A., de Witte, L. D., Kahn, R. S., Bahn, S., Drexhage, H. A., & Schiweck, C. (2022). Inflammatory monocyte gene signature predicts beneficial within group effect of simvastatin in patients with schizophrenia spectrum disorders in a secondary analysis of a randomized controlled trial. Brain, Behavior, and Immunity - Health, 26, Article 100551. https://doi.org/10.1016/j.bbih.2022.100551
Jansma, J., van Essen, R., Haarman, B. C. M., Chatziioannou, A. C., Borkent, J., Ioannou, M., van Hemert, S., Sommer, I. E. C., & El Aidy, S. (2022). Metabolic phenotyping reveals a potential link between elevated faecal amino acids, diet and symptom severity in individuals with severe mental illness. Journal of Psychiatric Research, 151, 507-515. https://doi.org/10.1016/j.jpsychires.2022.05.011
Schutte, M. J. L., Voppel, A., Collin, G., Abramovic, L., Boks, M. P. M., Cahn, W., van Haren, N. E. M., Hugdahl, K., Koops, S., Mandl, R. C. W., & Sommer, I. E. C. (2022). Modular-Level Functional Connectome Alterations in Individuals With Hallucinations Across the Psychosis Continuum. Schizophrenia Bulletin, 48(3), 684–694. https://doi.org/10.1093/schbul/sbac007
Linszen, M. M. J., de Boer, J. N., Schutte, M. J. L., Begemann, M. J. H., de Vries, J., Koops, S., Blom, R. E., Bohlken, M. M., Heringa, S. M., Blom, J. D., & Sommer, I. E. C. (2022). Occurrence and phenomenology of hallucinations in the general population: A large online survey. Schizophrenia, 8, Article 41. https://doi.org/10.1038/s41537-022-00229-9
Solmi, M., Estrade, A., Thompson, T., Agorastos, A., Radua, J., Cortese, S., Dragioti, E., Leisch, F., Vancampfort, D., Thygesen, L. C., Aschauer, H., Schloegelhofer, M., Akimova, E., Schneeberger, A., Huber, C. G., Hasler, G., Conus, P., Do Cuenod, K. Q., von Kanel, R., ... Sommer, I. (2022). Physical and mental health impact of COVID-19 on children, adolescents, and their families: The Collaborative Outcomes study on Health and Functioning during Infection Times-Children and Adolescents (COH-FIT-C&A). Journal of Affective Disorders, 299, 367-376. https://doi.org/10.1016/j.jad.2021.09.090
Sommer, I. E. C., & DeLisi, L. E. (2022). Precision psychiatry and the clinical care for people with schizophrenia: sex, race and ethnicity in relation to social determinants of mental health. Current opinion in psychiatry, 35(3), 137-139. https://doi.org/10.1097/YCO.0000000000000781
Yehya, A., Khaled, S. M., Sommer, I. E. C., Woodruff, P., & Daher-Nashif, S. (2022). Psychotic-like experiences among university female students in Qatar: A qualitative-phenomenological study. Frontiers in Psychiatry, 13, Article 988913. https://doi.org/10.3389/fpsyt.2022.988913
Gill, K., Percival, C., Roes, M., Arreaza, L., Chinchani, A., Sanford, N., Sena, W., Mohammadsadeghi, H., Menon, M., Hughes, M., Carruthers, S., Sumner, P., Woods, W., Jardri, R., Sommer, I. E., Rossell, S. L., & Woodward, T. S. (2022). Real-Time Symptom Capture of Hallucinations in Schizophrenia with fMRI: Absence of Duration-Dependent Activity. Schizophrenia Bulletin Open, 3(1), Article sgac050. https://doi.org/10.1093/schizbullopen/sgac050
Grootens, K. P., & Sommer, I. E. (2022). Redesigning phase 3 and 4 trials to adopt shared decision making. The Lancet. Psychiatry, 9(2), 101-103. https://doi.org/10.1016/S2215-0366(21)00385-0
Borkent, J., Ioannou, M., Laman, J. D., Haarman, B. C. M., & Sommer, I. E. C. (2022). Role of the gut microbiome in three major psychiatric disorders. Psychological Medicine, 52(7), 1222-1242. Article 0033291722000897. https://doi.org/10.1017/S0033291722000897
Puvogel, S., Alsema, A., Kracht, L., Webster, M. J., Weickert, C. S., Sommer, I. E. C., & Eggen, B. J. L. (2022). Single-nucleus RNA sequencing of midbrain blood-brain barrier cells in schizophrenia reveals subtle transcriptional changes with overall preservation of cellular proportions and phenotypes. Molecular Psychiatry, 27, 4731–4740. https://doi.org/10.1038/s41380-022-01796-0
Horowitz, M. A., Moncrieff, J., de Haan, L., Bogers, J. P. A. M., Gangadin, S. S., Kikkert, M., Veling, W., & Sommer, I. E. C. (2022). Tapering antipsychotic medication: practical considerations. Psychological Medicine, 52(1), 32-35. https://doi.org/10.1017/S0033291721003299
Solmi, M., Estrade, A., Thompson, T., Agorastos, A., Radua, J., Cortese, S., Dragioti, E., Leisch, F., Vancampfort, D., Thygesen, L. C., Aschauer, H., Schloegelhofer, M., Akimova, E., Schneeberger, A., Huber, C. G., Hasler, G., Conus, P., Do Cuenod, K. Q., von Kanel, R., ... Sommer, I. (2022). The collaborative outcomes study on health and functioning during infection times in adults (COH-FIT-Adults): Design and methods of an international online survey targeting physical and mental health effects of the COVID-19 pandemic. Journal of Affective Disorders, 299, 393-407. https://doi.org/10.1016/j.jad.2021.07.048
Oomen, P. P., Gangadin, S. S., Begemann, M. J. H., Visser, E., Mandl, R. C. W., & Sommer, I. E. C. (2022). The neurobiological characterization of distinct cognitive subtypes in early-phase schizophrenia-spectrum disorders. Schizophrenia Research, 241, 228-237. https://doi.org/10.1016/j.schres.2022.02.006

2021

de Boer, J. N., Voppel, A. E., Brederoo, S. G., Schnack, H. G., Truong, K. P., Wijnen, F. N. K., & Sommer, I. E. C. (2023). Acoustic speech markers for schizophrenia-spectrum disorders: a diagnostic and symptom-recognition tool. Psychological Medicine, 53(4), 1302–1312. https://doi.org/10.1017/S0033291721002804
Begemann, M. J. H., Schutte, M. J. L., Van Dellen, E., Abramovic, L., Boks, M. P., Van Haren, N. E. M., Mandl, R. C. W., Vinkers, C. H., Bohlken, M. M., & Sommer, I. E. C. (2023). Childhood trauma is associated with reduced frontal gray matter volume: A large transdiagnostic structural MRI study. Psychological Medicine, 53(3), 741-749. https://doi.org/10.1017/S0033291721002087
Oomen, P. P., Begemann, M. J. H., Brand, B. A., de Haan, L., Veling, W., Koops, S., van Os, J., Smit, F., Bakker, P. R., van Beveren, N., Boonstra, N., Gülöksüz, S., Kikkert, M., Lokkerbol, J., Marcelis, M., Rosema, B.-S., de Beer, F., Gangadin, S. S., Geraets, C. N. W., ... Sommer, I. E. C. (2023). Longitudinal clinical and functional outcome in distinct cognitive subgroups of first-episode psychosis: a cluster analysis. Psychological Medicine, 53(6), 2317 - 2327. https://doi.org/10.1017/S0033291721004153
Begemann, M. J. H., Sommer, I. E., Brand, R. M., Oomen, P. P., Jongeneel, A., Berkhout, J., Molenaar, R. E., Wielage, N. N., Toh, W. L., Rossell, S. L., & Bell, I. H. (2022). Auditory verbal hallucinations and childhood trauma subtypes across the psychosis continuum: a cluster analysis. Cognitive Neuropsychiatry, 27(2-3). https://doi.org/10.1080/13546805.2021.1925235
Kirschner, M., Hodzic-Santor, B., Antoniades, M., Nenadic, I., Kircher, T., Krug, A., Meller, T., Grotegerd, D., Fornito, A., Arnatkeviciute, A., Bellgrove, M. A., Tiego, J., Dannlowski, U., Koch, K., Hülsmann, C., Kugel, H., Enneking, V., Klug, M., Leehr, E. J., ... Modinos, G. (2022). Cortical and subcortical neuroanatomical signatures of schizotypy in 3004 individuals assessed in a worldwide ENIGMA study. Molecular Psychiatry, 27, 1167–1176. https://doi.org/10.1038/s41380-021-01359-9
Karolinska Schizophrenia Project K, Frangou, S., Modabbernia, A., Williams, S. C. R., Papachristou, E., Doucet, G. E., Agartz, I., Aghajani, M., Akudjedu, T. N., Albajes-Eizagirre, A., Alnaes, D., Alpert, K., Andersson, M., Andreasen, N. C., Andreassen, O. A., Asherson, P., Banaschewski, T., Bargallo, N., Baumeister, S., ... Wang, L. (2022). Cortical thickness across the lifespan: Data from 17,075 healthy individuals aged 3-90 years. Human brain mapping, 43(1), 431-451. https://doi.org/10.1002/hbm.25364
Luykx, J. J., Loef, D., Lin, B., van Diermen, L., Nuninga, J. O., van Exel, E., Oudega, M. L., Rhebergen, D., Schouws, S. N. T. M., van Eijndhoven, P., Verwijk, E., Schrijvers, D., Birkenhager, T. K., Ryan, K. M., Arts, B., van Bronswijk, S. C., Kenis, G., Schurgers, G., Baune, B. T., ... Rutten, B. P. F. (2022). Interrogating Associations Between Polygenic Liabilities and Electroconvulsive Therapy Effectiveness. Biological Psychiatry, 91(6), 531-539. https://doi.org/10.1016/j.biopsych.2021.10.013
HAMLETT OPHELIA Consortium, Kikkert, M. J., Veling, W., de Haan, L., Begemann, M. J. H., de Koning, M., & Sommer, I. E. (2022). Medication strategies in first episode psychosis patients: A survey among psychiatrists. Early intervention in psychiatry, 16(2), 139-146. https://doi.org/10.1111/eip.13138
de Boer, J., Corona Hernández, H., Gerritse, F., Brederoo, S., Wijnen, F., & Sommer, I. E. C. (2022). Negative content in auditory verbal hallucinations: a natural language processing approach. Cognitive Neuropsychiatry, 27(2-3), 139–149. https://doi.org/10.1080/13546805.2021.1941831
Hjelmervik, H., Craven, A. R., Johnsen, E., Kompus, K., Bless, J. J., Sinkeviciute, I., Kroken, R. A., Løberg, E. M., Ersland, L., Grüner, R., Sommer, I. E., & Hugdahl, K. (2022). Negative valence of hallucinatory voices as predictor of cortical glutamatergic metabolite levels in schizophrenia patients. Brain and Behavior, 12(1), Article e2446. https://doi.org/10.1002/brb3.2446
Koops, S., Brederoo, S. G., de Boer, J. N., Nadema, F. G., Voppel, A. E., & Sommer, I. E. (2022). Speech as a Biomarker for Depression. Cns & neurological disorders-Drug targets, 22(2), 152 - 160. https://doi.org/10.2174/1871527320666211213125847
Karolinska Schizophrenia Project K, Dima, D., Modabbernia, A., Papachristou, E., Doucet, G. E., Agartz, I., Aghajani, M., Akudjedu, T. N., Albajes-Eizagirre, A., Alnaes, D., Alpert, K., Andersson, M., Andreasen, N. C., Andreassen, O. A., Asherson, P., Banaschewski, T., Bargallo, N., Baumeister, S., Baur-Streubel, R., ... Wang, L. (2022). Subcortical volumes across the lifespan: Data from 18,605 healthy individuals aged 3-90 years. Human brain mapping, 43(1), 452-469. https://doi.org/10.1002/hbm.25320

2020

Karolinska Schizophrenia Project (KaSP) consortium, Wierenga, L. M., Doucet, G. E., Dima, D., Agartz, I., Aghajani, M., Akudjedu, T. N., Albajes-Eizagirre, A., Alnaes, D., Alpert, K. I., Andreassen, O. A., Anticevic, A., Asherson, P., Banaschewski, T., Bargallo, N., Baumeister, S., Baur-Streubel, R., Bertolino, A., Bonvino, A., ... Wang, L. (2022). Greater male than female variability in regional brain structure across the lifespan. Human brain mapping, 43(1), 470-499. https://doi.org/10.1002/hbm.25204
Last modified:04 September 2024 3.46 p.m.
View this page in: Nederlands