Wijmenga, Prof. Cisca
Prof. Cisca Wijmenga has been Professor of Human Genetics at the University of Groningen and head of the Genetics Department of the University Medical Center Groningen since 2007. The aim of her research is to understand the role that genes play in the development of chronic diseases. Her research group focuses on the genetics of inflammation-related conditions, such as coeliac disease (gluten allergy) and inflammatory intestinal disease (e.g. Crohn’s disease, ulcerative colitis). Research led by Wijmenga has discovered several genes that are involved in causing such immune-related disorders. This knowledge is leading to new insights into the disease process, and could possibly result in new treatments for patients.
Prof. Wijmenga has been elected a member of the Royal Netherlands Academy of Arts and Sciences (KNAW) in 2012. Members of KNAW are all prominent academics from all disciplines and are chosen on the basis of nominations from within and outside the Academy. In the same year she received a prestigious ERC Advanced Grant for her research project on Celiac disease. The BBMRI-NL2.0 project, a collaboration led by Wijmenga between biobanks in the Netherlands, received EUR 9.8 million from NWO in 2014. In 2015 Wijmenga has been awarded a Spinoza Prize, also referred to as the 'Dutch Nobel Prize'.
From 2019 - 2023, Wijmenga was rector magnificus of the RUG. She was the first female rector in the 405-year history of the UG.
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Contact and further information
Publications
2024
Moerkens,
R., Mooiweer, J.,
Ramírez-Sánchez, A. D., Oelen,
R., Franke, L., Wijmenga, C.,
Barrett, R. J., Jonkers, I. H., & Withoff,
S. (2024). An iPSC-derived small intestine-on-chip
with self-organizing epithelial, mesenchymal, and neural
cells. Cell reports, 43(7),
Article 114247. https://doi.org/10.1016/j.celrep.2024.114247
Lifelines
Corona Research initiative, Goërtz, Y. M. J., Spruit, M. A.,
Van Herck, M., Dukers-Muijrers, N., van der Kallen, C. J. H.,
Burtin, C., & Janssen, D. J. A. (2024). Author
Correction: Symptoms and quality of life before, during, and after
a SARS-CoV-2 PCR positive or negative test: data from Lifelines
(Scientific Reports, (2023), 13, 1, (11713),
10.1038/s41598-023-38223-5). Scientific
Reports, 14, Article 8390. https://doi.org/10.1038/s41598-024-58848-4
Fernández-Pato,
A., Sinha, T., Gacesa, R.,
Andreu-Sánchez, S., Gois, M. F. B.,
Gelderloos-Arends, J., Jansen, D. B. H., Kruk, M.,
Jaeger, M., Joosten, L. A. B., Netea, M. G., Weersma, R.
K., Wijmenga, C., Harmsen, H. J.
M., Fu, J., Zhernakova, A.,
& Kurilshikov, A. (2024). Choice of DNA extraction
method affects stool microbiome recovery and subsequent phenotypic
association analyses. Scientific
Reports, 14, Article 3911. https://doi.org/10.1038/s41598-024-54353-w
International
Multiple Sclerosis Genetics Consortium, Lincoln, M. R., Connally,
N., Axisa, P.-P., Gasperi, C., Mitrovic, M., van Heel, D.,
Wijmenga, C., Withoff, S., Jonkers, I.
H., Padyukov, L., Rich, S. S., Graham, R. R., Gaffney, P.
M., Langefeld, C. D., Vyse, T. J., Hafler, D. A., Chun, S.,
Sunyaev, S. R., & Cotsapas, C. (2024). Genetic mapping
across autoimmune diseases reveals shared associations and
mechanisms. Nature genetics,
56(5), 838-845. https://doi.org/10.1038/s41588-024-01732-8
Lifelines
Cohort Study, Zhernakova, D. V., Wang,
D., Liu, L., Andreu-Sánchez,
S., Zhang, Y., Ruiz-Moreno, A.
J., Peng, H., Plomp, N., Del
Castillo-Izquierdo, Á., Gacesa, R.,
Lopera-Maya, E. A., Temba, G. S., Kullaya, V. I., van
Leeuwen, S. S., Xavier, R. J., de Mast, Q., Joosten, L. A.
B., Riksen, N. P., ... Fu, J. (2024). Host
genetic regulation of human gut microbial structural
variation. Nature, 625,
813–821. https://doi.org/10.1038/s41586-023-06893-w
Simpson,
H. L., Smits, E., Moerkens, R.,
Wijmenga, C., Mooiweer, J., Jonkers, I.
H., & Withoff, S. (2024). Human
organoids and organ-on-chips in coeliac disease research.
Trends in Molecular Medicine. Advance online
publication. https://doi.org/10.1016/j.molmed.2024.10.003
BBMRI
Consortium, Bizzarri, D., Reinders, M. J. T., Kuiper, L., Beekman,
M., Deelen, J., van Meurs, J. B. J., van Dongen, J., Pool, R.,
Boomsma, D. I., Ghanbari, M., & Franke, L. (2024).
NMR metabolomics-guided DNA methylation mortality
predictors. EBioMedicine,
107, Article 105279. https://doi.org/10.1016/j.ebiom.2024.105279
Bios
Consortium , van Hilten, A., van Rooij, J., Ikram, M. A.,
Niessen, W. J., van Meurs, J. B. J., & Roshchupkin, G.
V. (2024). Phenotype prediction using biologically
interpretable neural networks on multi-cohort multi-omics
data. npj Systems Biology and
Applications, 10, Article 81. https://doi.org/10.1038/s41540-024-00405-w
Tan,
I. L., Modderman, R., Stachurska, A., Almeida, R., de
Vries, R., Heersema, D. J., Gacesa,
R., Wijmenga, C., Jonkers, I. H.,
Meilof, J. F., & Withoff, S. (2024).
Potential biomarkers for multiple sclerosis stage from
targeted proteomics and microRNA sequencing. Brain
Communications, 6(4), Article fcae209. https://doi.org/10.1093/braincomms/fcae209
Lifelines
NEXT cohort study, Garmaeva, S., Sinha,
T., Gulyaeva, A., Kuzub, N.,
Spreckels, J. E., Andreu-Sánchez,
S., Gacesa, R., Vich Vila,
A., Brushett, S., Kruk, M., Dekens,
J., Sikkema, J., Kuipers, F.,
Shkoporov, A. N., Hill, C., Scherjon, S.,
Wijmenga, C., Fu, J., ... Zhernakova,
A. (2024). Transmission and dynamics of mother-infant
gut viruses during pregnancy and early life.
Nature Communications, 15(1),
Article 1945. https://doi.org/10.1038/s41467-024-45257-4
2023
BBJ,
BioMe, BioVU, Canadian Partnership for Tomorrow's Health/OHS, China
Kadoorie Biobank Collaborative Group, Colorado Center for
Personalized Medicine, deCODE Genetics, ESTBB, FinnGen, Generation
Scotland, Genes & Health, LifeLines, Mass General Brigham
Biobank, Michigan Genomics Initiative, QIMR Berghofer Biobank,
Taiwan Biobank, The HUNT Study, UCLA ATLAS Community Health
Initiative, UKBB, ... Hirbo, J. B. (2023). Global Biobank
analyses provide lessons for developing polygenic risk scores
across diverse cohorts. Cell Genomics,
3(1), Article 100241. https://doi.org/10.1016/j.xgen.2022.100241
Brushett,
S., Gacesa, R., Vila, A. V.,
Gois, M. F. B., Andreu-Sánchez, S.,
Swarte, J. C., Klaassen, M. A. Y., Collij,
V., Sinha, T., Bolte, L. A., Wu,
J., Swertz, M., Kroon, M. L. A. D.,
Reijneveld, S. A., Wijmenga, C., Weersma,
R. K., Fu, J., Loo, H. M.
V., Kurilshikov, A., & Zhernakova,
A. (2023). Gut feelings: the relations between
depression, anxiety, psychotropic drugs and the gut
microbiome. Gut Microbes,
15(2), Article 2281360. https://doi.org/10.1080/19490976.2023.2281360
Hamburg
Intestinal Tissue Study Group, International Inflammatory Bowel
Disease Genetics Consortium, Baumdick, M. E., Niehrs, A.,
Degenhardt, F., Schwerk, M., Hinrichs, O., Jordan-Paiz, A., Padoan,
B., Wegner, L. H. M., Schloer, S., Zecher, B. F., Malsy, J., Joshi,
V. R., Illig, C., Schröder-Schwarz, J., Möller, K. J.,
Martin, M. P., Yuki, Y., ... Franke, A. (2023). HLA-DP on
Epithelial Cells Enables Tissue Damage by NKp44+ Natural
Killer Cells in Ulcerative Colitis.
Gastroenterology, 165(4),
946-962.e13. https://doi.org/10.1053/j.gastro.2023.06.034
Gois,
M. F. B., Fernández-Pato, A., Huss,
A., Gacesa, R., Wijmenga, C.,
Weersma, R. K., Fu, J., Vermeulen, R. C.
H., Zhernakova, A., Lenters, V. C., &
Kurilshikov, A. (2023). Impact of occupational
pesticide exposure on the human gut microbiome.
Frontiers in Microbiology, 14,
Article 1223120. https://doi.org/10.3389/fmicb.2023.1223120
TANDEM
Consortium$, Eckold, C., van Doorn, C. L. R., Ruslami, R.,
Ronacher, K., Riza, A.-L., van Veen, S., Lee,
J.-S., Kumar, V., Kerry-Barnard, S., Malherbe, S. T.,
Kleynhans, L., Stanley, K., Joosten, S. A., Critchley, J. A., Hill,
P. C., van Crevel, R., Wijmenga, C., Haks, M. C., ...
Cliff, J. M. (2023). Impaired resolution of blood
transcriptomes through tuberculosis treatment with diabetes
comorbidity. Clinical and Translational
Medicine, 13(9), Article e1375. https://doi.org/10.1002/ctm2.1375
Palasantzas,
V. E. J. M., Tamargo-Rubio, I., Le,
K., Slager, J., Wijmenga,
C., Jonkers, I. H., Kumar,
V., Fu, J., & Withoff, S.
(2023). iPSC-derived organ-on-a-chip models for personalized
human genetics and pharmacogenomics studies.
Trends in Genetics, 39(4), 268-284.
https://doi.org/10.1016/j.tig.2023.01.002
eQTLgen
Consortium, Dai, Q., Zhou, G., Zhao, H., Võsa,
U., Franke, L., Battle, A., Teumer, A.,
Lehtimäki, T., Raitakari, O. T., Esko, T., Epstein, M. P.,
& Yang, J. (2023). OTTERS: a powerful TWAS framework
leveraging summary-level reference data. Nature
Communications, 14, Article 1271. https://doi.org/10.1038/s41467-023-36862-w
Bourgonje,
A. R., Andreu-Sánchez, S., Vogl, T.,
Hu, S., Vich Vila, A., Gacesa, R.,
Leviatan, S., Kurilshchikov, A., Klompus, S., Kalka,
I. N., van Dullemen, H. M., Weinberger, A.,
Visschedijk, M. C., Festen, E. A. M.,
Faber, K. N., Wijmenga, C., Dijkstra,
G., Segal, E., Fu, J., ... Weersma, R.
K. (2023). Phage-display immunoprecipitation
sequencing of the antibody epitope repertoire in inflammatory bowel
disease reveals distinct antibody signatures.
Immunity, 56(6), 1393-1409.e6. https://doi.org/10.1016/j.immuni.2023.04.017
Lifelines
Cohort Study, Andreu-Sánchez, S.,
Bourgonje, A. R., Vogl, T., Kurilshchikov, A.,
Leviatan, S., Ruiz-Moreno, A. J., Hu,
S., Sinha, T., Vich Vila, A.,
Klompus, S., Kalka, I. N., de Leeuw, K., Arends,
S., Jonkers, I., Withoff,
S., Brouwer, E., Weinberger, A.,
Wijmenga, C., ... Zhernakova, A. (2023).
Phage display sequencing reveals that genetic, environmental,
and intrinsic factors influence variation of human antibody epitope
repertoire. Immunity, 56(6),
1376-1392.e8. https://doi.org/10.1016/j.immuni.2023.04.003
The
Netherlands A. C. M./P. L. N. Registry, Lifelines Cohort
Study, Lopera-Maya, E. A., Li, S.,
de Brouwer, R., Nolte, I. M., van Breen,
J., Jongbloed, J. D. H., Swertz, M.
A., Snieder, H., Franke, L.,
Wijmenga, C., de Boer, R. A., Deelen,
P., van der Zwaag, P. A., & Sanna,
S. (2023). Phenotypic and Genetic Factors Associated
with Absence of Cardiomyopathy Symptoms in PLN:c.40_42delAGA
Carriers. Journal of cardiovascular translational
research, 16, 1251–1266. https://doi.org/10.1007/s12265-022-10347-5
Lifelines
Corona Research initiative, Goërtz, Y. M. J., Spruit, M. A.,
Van Herck, M., Dukers-Muijrers, N., van der Kallen, C. J. H.,
Burtin, C., & Janssen, D. J. A. (2023). Symptoms and
quality of life before, during, and after a SARS-CoV-2 PCR positive
or negative test: data from Lifelines. Scientific
Reports, 13, Article 11713. https://doi.org/10.1038/s41598-023-38223-5
Lifelines
Corona Research initiative, Mobach, M. P., Boezen, H.
M., Mierau, J. O., Franke, H.
L., Dekens, J., Deelen, P.,
Lanting, P., Vonk, J. M., Nolte,
I., Ori, A. P. S., Claringbould,
A., Boulogne, F., Dijkema, M. X. L.,
Wiersma, H. H., Warmerdam, R.,
Jankipersadsing, S. A., van Blokland, I.,
de Bock, G. T. H., ... Wijmenga, C. (2023).
Workplace impact on employees: A Lifelines Corona Research
Initiative on the return to work. PLoS
ONE, 18(1), Article e0279902. https://doi.org/10.1371/journal.pone.0279902
2022
Chu,
X., Janssen, A. W. M., Koenen, H., Chang, L., He, X.,
Joosten, I., Stienstra, R., Kuijpers, Y., Wijmenga,
C., Xu, C.-J., Netea, M. G., Tack, C. J., Li,
Y., & Buettner, C. (2022). A genome-wide
functional genomics approach uncovers genetic determinants of
immune phenotypes in type 1 diabetes.
eLife, 11, Article 73709. https://doi.org/10.7554/eLife.73709
Lifelines
Cohort Study, Lopera-Maya, E. A., Kurilshikov,
A., van der Graaf, A., Hu,
S., Andreu-Sánchez, S., Chen,
L., Vila, A. V., Gacesa, R.,
Sinha, T., Collij, V., Klaassen, M. A.
Y., Bolte, L. A., Gois, M. F. B.,
Neerincx, P. B. T., Swertz, M. A.,
Harmsen, H. J. M., Wijmenga, C., Fu,
J., ... Sanna, S. (2022). Author
Correction: Effect of host genetics on the gut microbiome in 7,738
participants of the Dutch Microbiome Project (Nature Genetics,
(2022), 54, 2, (143-151), 10.1038/s41588-021-00992-y).
Nature genetics, 54(9), 1448. https://doi.org/10.1038/s41588-022-01164-2
Gulyaeva,
A., Garmaeva, S., Ruigrok, R. A. A. A.,
Wang, D., Riksen, N. P., Netea, M. G., Wijmenga,
C., Weersma, R. K., Fu, J.,
Vila, A. V., Kurilshikov, A., &
Zhernakova, A. (2022). Discovery, diversity, and
functional associations of crAss-like phages in human gut
metagenomes from four Dutch cohorts. Cell
reports, 38(2), Article 110204. https://doi.org/10.1016/j.celrep.2021.110204
Lopera-Maya,
E. A., Kurilshikov, A., van der Graaf,
A., Hu, S., Lifelines Cohort Study,
Andreu-Sánchez, S., Chen, L., Vila,
A. V., Gacesa, R., Sinha,
T., Collij, V., Klaassen, M. A. Y.,
Bolte, L. A., Brandao Gois, M. F.,
Neerincx, P. B. T., Swertz, M. A.,
Harmsen, H. J. M., Wijmenga, C., Fu,
J., ... Sanna, S. (2022). Effect of host
genetics on the gut microbiome in 7,738 participants of the Dutch
Microbiome Project. Nature genetics,
54, 143-151. https://doi.org/10.1038/s41588-021-00992-y
Lifelines
Cohort Study, Lopera-Maya, E. A., Kurilshikov,
A., van der Graaf, A., Hu,
S., Andreu-Sánchez, S., Chen,
L., Vich-Vila, A., Gacesa,
R., Sinha, T., Collij, V.,
Klassen, M. A. Y., Bolte, L. A., Brandao-Gois,
M. F., Neerincx, P. B. T., Swertz, M.
A., Harmsen, H. J. M., Wijmenga,
C., Fu, J., ... Sanna, S. (2022).
Effect of host genetics on the gut microbiome in 7,738
participants of the Dutch Microbiome Project.
European Journal of Human Genetics,
30(SUPPL 1), 589-589.
Gacesa,
R., Kurilshikov, A., Vich Vila,
A., Sinha, T., Klaassen, M. A. Y., Bolte,
L. A., Andreu-Sánchez, S., Chen,
L., Collij, V., Hu, S.,
Dekens, J. A. M., Lenters, V. C., Björk, J.
R., Swarte, J. C., Swertz, M.
A., Jansen, B. H., Gelderloos-Arends, J.,
Jankipersadsing, S., Hofker, M., ... Weersma, R.
K. (2022). Environmental factors shaping the gut
microbiome in a Dutch population.
Nature, 732–739. https://doi.org/10.1038/s41586-022-04567-7
Andreu-Sánchez,
S., Aubert, G., Ripoll-Cladellas, A., Henkelman, S.,
Zhernakova, D. V., Sinha, T.,
Kurilshikov, A., Cenit, M. C., Jan Bonder,
M., Franke, L., Wijmenga,
C., Fu, J., van der Wijst, M. G.
P., Melé, M., Lansdorp, P., &
Zhernakova, A. (2022). Genetic, parental and lifestyle
factors influence telomere length. Communications
biology, 5(1), Article 565. https://doi.org/10.1038/s42003-022-03521-7
BIOS
Consortium, Brain MEND Consortium, Hop, P. J., Zwamborn, R. A. J.,
Hannon, E., Shireby, G. L., Nabais, M. F., Walker, E. M., van
Rheenen, W., van Vugt, J. J. F. A., Dekker, A. M., Westeneng, H.
J., Tazelaar, G. H. P., van Eijk, K. R., Moisse, M., Baird, D., Al
Khleifat, A., Iacoangeli, A., Ticozzi, N., ... Veldink, J. H.
(2022). Genome-wide study of DNA methylation shows
alterations in metabolic, inflammatory, and cholesterol pathways in
ALS. Science Translational Medicine,
14(633), Article eabj0264. https://doi.org/10.1126/scitranslmed.abj0264
deCODE
Genetics, Estonian Biobank, FinnGen, Generation Scotland, Genes
& Health Research Team, LifeLines, Mass General Brigham
Biobank, Michigan Genomics Initiative, National Biobank of Korea,
Penn Medicine BioBank, Qatar Biobank, The QSkin Sun and Health
Study, Taiwan Biobank, The HUNT Study, UCLA ATLAS Community Health
Initiative, Uganda Genome Resource, UK Biobank, Biobank of the
Americas, BioBank Japan Project, ... Sanna, S. (2022).
Global Biobank Meta-analysis Initiative: Powering genetic
discovery across human disease. Cell
Genomics, 2(10), Article 100192. https://doi.org/10.1016/j.xgen.2022.100192
Swarte,
J. C., Li, Y., Hu, S.,
Björk, J. R., Gacesa, R., Vich Vila,
A., Douwes, R. M., Collij,
V., Kurilshikov, A., Post, A.,
Klaassen, M. A. Y., Eisenga, M. F., Gomes-Neto,
A. W., Kremer, D., Jansen, B.
H., Knobbe, T. J., Berger, S.
P., Sanders, J.-S. F., Heiner-Fokkema, M.
R., ... Weersma, R. K. (2022). Gut
microbiome dysbiosis is associated with increased mortality after
solid organ transplantation. Science Translational
Medicine, 14(660), Article eabn7566. https://doi.org/10.1126/scitranslmed.abn7566
Bourgonje,
A. R., Andreu-Sánchez, S., Vogl, T.,
Hu, S., Vich Vila, A., Leviatan, S.,
Kurilshchikov, A., Klompus, S., Kalka, I. N., van
Dullemen, H. M., Weinberger, A., Visschedijk, M.
C., Festen, E. A. M., Faber, K.
N., Wijmenga, C., Dijkstra, G.,
Segal, E., Fu, J., Zhernakova, A.,
& Weersma, R. K. (2022). In-depth characterisation
of the serum antibody epitope repertoire in Inflammatory Bowel
Disease by high-throughput phage-displayed immunoprecipitation
sequencing. Journal of Crohn's and
Colitis, 16(Suppl(1)), S100-S102. https://doi.org/10.1093/ecco-jcc/jjab232.092
Lifelines
Cohort Study, Chen, L., Zhernakova, D.
V., Kurilshikov, A., Andreu-Sánchez,
S., Wang, D., Augustijn, H. E., Vich
Vila, A., Weersma, R. K., Medema, M. H., Netea,
M. G., Kuipers, F., Wijmenga, C.,
Zhernakova, A., & Fu, J. (2022).
Influence of the microbiome, diet and genetics on
inter-individual variation in the human plasma metabolome.
Nature Medicine, 28,
2333–2343. https://doi.org/10.1038/s41591-022-02014-8
Mujagic,
Z., Kasapi, M., Jonkers, D. M. A. E., Garcia-Perez, I., Vork, L.,
Weerts, Z. Z. R. M., Serrano-Contreras, J. I., Zhernakova,
A., Kurilshikov, A., Scotcher, J., Holmes,
E., Wijmenga, C., Keszthelyi, D., Nicholson, J. K.,
Posma, J. M., & Masclee, A. A. M. (2022). Integrated
fecal microbiome–metabolome signatures reflect stress and
serotonin metabolism in irritable bowel syndrome.
Gut Microbes, 14(1), Article
2063016. https://doi.org/10.1080/19490976.2022.2063016
Global
Biobank Meta-analysis Initiative, Kanai, M., Elzur, R., Zhou, W.,
Daly, M. J., & Finucane, H. K. (2022). Meta-analysis
fine-mapping is often miscalibrated at single-variant
resolution. Cell Genomics,
2(12), Article 100210. https://doi.org/10.1016/j.xgen.2022.100210
Estonian
Biobank Research Team, Lepamets, M., Auwerx, C., Nõukas,
M., Claringbould, A., Porcu, E., Kals, M.,
Jürgenson, T., Morris, A. P., Võsa, U.,
Bochud, M., Stringhini, S., Wijmenga, C.,
Franke, L., Peterson, H., Vilo, J., Lepik, K., Mägi,
R., & Kutalik, Z. (2022). Omics-informed CNV calls reduce
false-positive rates and improve power for CNV-trait
associations. Human Genetics and Genomics
Advances, 3(4), Article 100133. https://doi.org/10.1016/j.xhgg.2022.100133
Ramírez-Sánchez,
A. D., Chu, X., Modderman, R., Kooy-Winkelaar,
Y., Koletzko, S., Korponay-Szabó, I. R., Troncone, R.,
Wijmenga, C., Mearin, L., Withoff, S.,
Jonkers, I. H., & Li, Y. (2022). Single-Cell RNA
Sequencing of Peripheral Blood Mononuclear Cells From Pediatric
Coeliac Disease Patients Suggests Potential Pre-Seroconversion
Markers. Frontiers in Immunology,
13, Article 843086. https://doi.org/10.3389/fimmu.2022.843086
Doestzada,
M., Zhernakova, D. V., C L van den Munckhof,
I., Wang, D., Kurilshikov, A.,
Chen, L., Bloks, V. W., van Faassen,
M., Rutten, J. H. W., Joosten, L. A. B., Netea, M. G.,
Wijmenga, C., Riksen, N. P., Zhernakova,
A., Kuipers, F., & Fu, J.
(2022). Systematic analysis of relationships between plasma
branched-chain amino acid concentrations and cardiometabolic
parameters: an association and Mendelian randomization
study. BMC Medicine, 20(1),
Article 485. https://doi.org/10.1186/s12916-022-02688-4
TANDEM
Consortium, van Doorn, C. L. R., Eckold, C., Ronacher, K., Ruslami,
R., van Veen, S., Lee, J.-S., Kumar, V.,
Kerry-Barnard, S., Malherbe, S. T., Kleynhans, L., Stanley, K.,
Hill, P. C., Joosten, S. A., van Crevel, R., Wijmenga,
C., Critchley, J. A., Walzl, G., Alisjahbana, B., ... Cliff,
J. M. (2022). Transcriptional profiles predict treatment
outcome in patients with tuberculosis and diabetes at diagnosis and
at two weeks after initiation of anti-tuberculosis
treatment. EBioMedicine, 82,
Article 104173. https://doi.org/10.1016/j.ebiom.2022.104173
2021
Moorlag,
S. J. C. F. M., Matzaraki, V., van Puffelen Heijden,
J. H., van der Heijden, C., Keating, S., Groh, L., Bakker, O.
B., Koeken, V. A. C. M., de Bree, L. C. J., Smeekens, S. P.,
Oosting, M., Gamboa, R. A., Riksen, N. P., Xavier, R.
J., Wijmenga, C., Kumar, V., van Crevel,
R., Novakovic, B., Joosten, L. A. B., ... Netea, M. G. (2022).
An integrative genomics approach identifies KDM4 as a
modulator of trained immunity. European Journal of
Immunology, 52(3), 431-446. https://doi.org/10.1002/eji.202149577
Brandao
Gois, M. F., Sinha, T., Spreckels, J.
E., Vich Vila, A., Bolte, L.
A., Weersma, R. K., Wijmenga,
C., Fu, J., Zhernakova, A.,
& Kurilshikov, A. (2022). Role of the gut
microbiome in mediating lactose intolerance symptoms.
Gut, 71(1), 215-217. https://doi.org/10.1136/gutjnl-2020-323911
Gacesa,
R., Vich Vila, A., Collij, V.,
Mujagic, Z., Kurilshikov, A., Voskuil, M.
D., Festen, E. A. M., Wijmenga,
C., Jonkers, D. M. A. E., Dijkstra, G.,
Fu, J., Zhernakova, A., Imhann,
F., & Weersma, R. K. (2021). A
combination of fecal calprotectin and human beta-defensin 2
facilitates diagnosis and monitoring of inflammatory bowel
disease. Gut Microbes, 13(1),
Article 1943288. https://doi.org/10.1080/19490976.2021.1943288
Tan,
I. L., Barisani, D., Panceri, R., Modderman, R.,
Visschedijk, M., Weersma, R. K.,
Wijmenga, C., Jonkers, I., Coutinho de Almeida,
R., & Withoff, S. (2021). A Combined mRNA-
and miRNA-Sequencing Approach Reveals miRNAs as Potential
Regulators of the Small Intestinal Transcriptome in Celiac
Disease. International Journal of Molecular
Sciences, 22(21), Article 11382. https://doi.org/10.3390/ijms222111382
Wang,
D., Doestzada, M., Chen, L.,
Andreu-Sánchez, S., van den Munckhof, I. C. L.,
Augustijn, H. E., Koehorst, M., Ruiz-Moreno, A.
J., Bloks, V. W., Riksen, N. P., Rutten, J. H.
W., Joosten, L. A. B., Netea, M. G., Wijmenga,
C., Zhernakova, A., Kuipers,
F., & Fu, J. (2021). Characterization
of gut microbial structural variations as determinants of human
bile acid metabolism. Cell Host &
Microbe, 29(12), 1802-1814.e5. https://doi.org/10.1016/j.chom.2021.11.003
Tan,
I. L., Coutinho de Almeida, R., Modderman, R., Stachurska,
A., Dekens, J., Barisani, D., Meijer, C. R., Roca, M.,
Martinez-Ojinaga, E., Shamir, R., Auricchio, R.,
Korponay-Szabó, I. R., Castillejo, G., Szajewska, H.,
Koletzko, S., Zhernakova, A., Kumar,
V., Li, Y., Visschedijk, M.
C., ... Withoff, S. (2021). Circulating
miRNAs as Potential Biomarkers for Celiac Disease
Development. Frontiers in Immunology,
12, Article 734763. https://doi.org/10.3389/fimmu.2021.734763
Gulyaeva,
A., Garmaeva, S., Ruigrok, R. A. A. A.,
Wang, D., Riksen, N. P., Netea, M. G., Wijmenga,
C., Weersma, R. K., Fu, J.,
Vila, A. V., Kurilshikov, A., &
Zhernakova, A. (2021). Discovery, diversity and
functional associations of crAss-like phages in human gut
metagenomes from four Dutch cohorts. BioRxiv. https://doi.org/10.1101/2021.06.01.446427
Fu,
J., Chen, L., Andreu-Sánchez,
S., Wang, D., Augustijn, H. E.,
Zhernakova, D., Kurilshikov, A., Vila, A.
V., Weersma, R., Medema, M., Netea, M.,
Kuipers, F., Wijmenga, C., &
Zhernakova, A. (2021). Dominant drivers of the
human plasma metabolome. BioRxiv. https://doi.org/10.21203/rs.3.rs-688716/v1
Wijmenga,
C. (2021). From LD-based mapping to GWAS.
Nature Reviews Genetics, 22(8). https://doi.org/10.1038/s41576-021-00366-4
Ortiz
Fernández, L., Coit, P., Yilmaz, V., Yentür, S. P.,
Alibaz-Oner, F., Aksu, K., Erken, E., Düzgün, N., Keser,
G., Cefle, A., Yazici, A., Ergen, A., Alpsoy, E., Salvarani, C.,
Casali, B., Kısacık, B., Kötter, I., Henes, J.,
Çınar, M., ... Sawalha, A. H. (2021). Genetic
Association of a Gain-of-Function IFNGR1 Polymorphism and the
Intergenic Region LNCAROD/DKK1 With Behcet's Disease.
Arthritis & Rheumatology, 73(7),
1244-1252. https://doi.org/10.1002/art.41637
Peters,
V., Tigchelaar-Feenstra, E. F., Imhann,
F., Dekens, J. A. M., Swertz, M.
A., Franke, L. H., Wijmenga,
C., Weersma, R. K., Alizadeh, B.
Z., Dijkstra, G., &
Campmans-Kuijpers, M. J. E. (2021). Habitual dietary
intake of IBD patients differs from population controls: A
case-control study. European Journal of
Nutrition, 60, 345–356. https://doi.org/10.1007/s00394-020-02250-z
Brand,
E. C., Klaassen, M. A. Y., Gacesa, R., Vila, A.
V., Ghosh, H., de Zoete, M. R., Boomsma, D. I.,
Hoentjen, F., Horjus Talabur Horje, C. S., van de Meeberg, P. C.,
Willemsen, G., Fu, J., Wijmenga, C., van
Wijk, F., Zhernakova, A., Oldenburg, B.,
Weersma, R. K., & Dutch TWIN-IBD consortium and the
Dutch Initiative on Crohn and Colitis (2021). Healthy Cotwins
Share Gut Microbiome Signatures With Their Inflammatory Bowel
Disease Twins and Unrelated Patients.
Gastroenterology, 160(6), 1970-1985.
https://doi.org/10.1053/j.gastro.2021.01.030
Bourgonje,
A. R., Andreu-Sánchez, S., Vogl, T.,
Hu, S., Vila, A. V., Gacesa, R.,
Leviatan, S., Kurilshikov, A., Klompus, S., Kalka, I. N., van
Dullemen, H. M., Weinberger, A., Visschedijk, M.
C., Festen, E. A. M., Faber, K.
N., Wijmenga, C., Dijkstra, G.,
Segal, E., Fu, J., ... Weersma, R. K.
(2021). In-depth characterization of the serum antibody
epitope repertoire in inflammatory bowel disease using
phage-displayed immunoprecipitation sequencing.
BioRxiv. https://doi.org/10.1101/2021.12.07.471581
Matzaraki,
V., Le, K. T. T., Jaeger, M.,
Aguirre-Gamboa, R., Johnson, M. D., Sanna, S.,
Rosati, D., Franke, L., Zhernakova,
A., Fu, J., Withoff, S.,
Jonkers, I., Li, Y., Joosten, L. A. B., Netea,
M. G., Wijmenga, C., & Kumar, V.
(2021). Inflammatory Protein Profiles in Plasma of
Candidaemia Patients and the Contribution of Host Genetics to Their
Variability. Frontiers in Immunology,
12, Article 662171. https://doi.org/10.3389/fimmu.2021.662171
Chu,
X., Jaeger, M., Beumer, J., Bakker, O.
B., Aguirre-Gamboa, R., Oosting, M., Smeekens,
S. P., Moorlag, S., Mourits, V. P., Koeken, V. A. C. M., de Bree,
C., Jansen, T., Mathews, I. T., Dao, K., Najhawan, M., Watrous, J.
D., Joosten, I., Sharma, S., Koenen, H. J. P. M., ... Li,
Y. (2021). Integration of metabolomics, genomics, and
immune phenotypes reveals the causal roles of metabolites in
disease. Genome Biology,
22(1), Article 198. https://doi.org/10.1186/s13059-021-02413-z
MiBioGen
Consortium Initiative, Kurilshikov, A., Medina-Gomez,
C., Bacigalupe, R., Radjabzadeh, D., Wang, J., Demirkan,
A., Le Roy, C. I., Raygoza Garay, J. A., Finnicum, C. T.,
Liu, X., Zhernakova, D. V., Bonder, M.
J., Hansen, T. H., Frost, F., Ruehlemann, M. C., Turpin, W.,
Moon, J.-Y., Kim, H.-N., ... Zhernakova, A. (2021).
Large-scale association analyses identify host factors
influencing human gut microbiome composition.
Nature Genetics, 53, 156-165. https://doi.org/10.1038/s41588-020-00763-1
BIOS
Consortium, i2QTL Consortium, Võsa, U.,
Claringbould, A., Westra, H.-J., Bonder,
M. J., Deelen, P., Zeng, B., Kirsten, H., Saha,
A., Kreuzhuber, R., Yazar, S., Brugge, H.,
Oelen, R., de Vries, D. H., van der
Wijst, M. G. P., Kasela, S., Pervjakova, N., Alves,
I., ... Franke, L. (2021). Large-scale cis- and
trans-eQTL analyses identify thousands of genetic loci and
polygenic scores that regulate blood gene expression.
Nature Genetics, 53(9), 1300-1310.
https://doi.org/10.1038/s41588-021-00913-z
Mc
Intyre, K., Lanting, P., Deelen,
P., Wiersma, H. H., Vonk, J.
M., Ori, A. P. S., Jankipersadsing, S.
A., Warmerdam, R., van Blokland,
I., Boulogne, F., Dijkema, M. X. L.,
Herkert, J. C., Claringbould, A., Bakker,
O., Lopera Maya, E. A., Bültmann,
U., Zhernakova, A., Reijneveld, S.
A., Zijlstra, E., ... Franke, L.
(2021). Lifelines COVID-19 cohort: investigating COVID-19
infection and its health and societal impacts in a Dutch
population-based cohort. BMJ Open,
11(3), Article e044474. https://doi.org/10.1136/bmjopen-2020-044474
Atanasovska,
B., Rensen, S. S., Marsman, G., Shiri-Sverdlov, R., Withoff,
S., Kuipers, F., Wijmenga,
C., van de Sluis, B., & Fu, J.
(2021). Long Non-Coding RNAs Involved in Progression of
Non-Alcoholic Fatty Liver Disease to Steatohepatitis.
Cells, 10(8), 1-15. Article 1883. https://doi.org/10.3390/cells10081883
Bolte,
L. A., Vich Vila, A., Imhann,
F., Collij, V., Gacesa, R.,
Peters, V., Wijmenga, C., Kurilshikov,
A., Campmans-Kuijpers, M. J. E., Fu,
J., Dijkstra, G., Zhernakova,
A., & Weersma, R. K. (2021).
Long-term dietary patterns are associated with
pro-inflammatory and anti-inflammatory features of the gut
microbiome. Gut, 70(7),
1287-1298. https://doi.org/10.1136/gutjnl-2020-322670
Bolte,
L. A., Klaassen, M. A. Y., Collij, V.,
Vich Vila, A., Fu, J., van der Meulen, T.
A., de Haan, J. J., Versteegen, G.
J., Dotinga, A., Zhernakova,
A., Wijmenga, C., Weersma, R.
K., & Imhann, F. (2021). Patient
attitudes towards faecal sampling for gut microbiome studies and
clinical care reveal positive engagement and room for
improvement. PLoS ONE, 16(4),
Article e0249405. https://doi.org/10.1371/journal.pone.0249405
Vogl,
T., Klompus, S., Leviatan, S., Kalka, I. N., Weinberger, A.,
Wijmenga, C., Fu, J., Zhernakova,
A., Weersma, R. K., & Segal, E. (2021).
Population-wide diversity and stability of serum antibody
epitope repertoires against human microbiota.
Nature Medicine, 27(8), 1442-1450.
https://doi.org/10.1038/s41591-021-01409-3
Bakker,
O. B., Ramírez-Sánchez, A. D., Borek,
Z. A., de Klein, N., Li, Y., Modderman,
R., Kooy-Winkelaar, Y., Johannesen, M. K., Matarese, F., Martens,
J. H. A., Kumar, V., van Bergen, J., Qiao, S.-W.,
Lundin, K. E. A., Sollid, L. M., Koning, F., Wijmenga,
C., Withoff, S., & Jonkers, I.
H. (2021). Potential impact of celiac disease genetic
risk factors on T cell receptor signaling in gluten-specific CD4+ T
cells. Scientific Reports,
11(1), 1-15. Article 9252. https://doi.org/10.1038/s41598-021-86612-5
Garmaeva,
S., Gulyaeva, A., Sinha, T.,
Shkoporov, A. N., Clooney, A. G., Stockdale, S. R.,
Spreckels, J. E., Sutton, T. D. S., Draper, L. A., Dutilh,
B. E., Wijmenga, C., Kurilshikov,
A., Fu, J., Hill, C., & Zhernakova,
A. (2021). Stability of the human gut virome and
effect of gluten-free diet. Cell
reports, 35(7), 1-21. Article 109132. https://doi.org/10.1016/j.celrep.2021.109132
BIOS
Consortium, van der Graaf, A., Zorro, M.
M., Claringbould, A., Vosa,
U., Aguirre-Gamboa, R., Li,
C., Mooiweer, J., Ricano-Ponce,
I., Borek, Z., Koning, F., Kooy-Winkelaar, Y., Sollid, L.
M., Qiao, S.-W., Kumar, V., Li, Y.,
Franke, L., Withoff, S., Wijmenga,
C., ... Jonkers, I. (2021). Systematic
Prioritization of Candidate Genes in Disease Loci Identifies TRAFD1
as a Master Regulator of IFN gamma Signaling in Celiac
Disease. Frontiers in Genetics,
11, 562434. Article 562434. https://doi.org/10.3389/fgene.2020.562434
Ruigrok,
R. A. A. A., Collij, V., Sureda, P., Klaassen, M. A.
Y., Bolte, L. A., Jansen, B. H.,
Voskuil, M. D., Fu, J., Wijmenga,
C., Zhernakova, A., Weersma, R.
K., & Vich Vila, A. (2021). The
composition and metabolic potential of the human small intestinal
microbiota within the context of inflammatory bowel disease.
Journal of Crohn's and Colitis,
15(8), 1326-1338. https://doi.org/10.1093/ecco-jcc/jjab020
Lifelines
Cohort Study, Chen, L., Wang, D.,
Garmaeva, S., Kurilshikov, A., Vich Vila,
A., Gacesa, R., Sinha, T., Segal,
E., Weersma, R. K., Wijmenga, C.,
Zhernakova, A., & Fu, J. (2021). The
long-term genetic stability and individual specificity of the human
gut microbiome. Cell, 184(9),
2302-+. https://doi.org/10.1016/j.cell.2021.03.024
2020
TANDEM
Consortium, Eckold, C., Kumar, V., Weiner Rd, J.,
Alisjahbana, B., Riza, A.-L., Ronacher, K., Coronel,
J., Kerry-Barnard, S., Malherbe, S. T., Kleynhans, L., Stanley, K.,
Ruslami, R., Ioana, M., Ugarte-Gil, C., Walzl, G., van Crevel,
R., Wijmenga, C., Critchley, J. A., ... Cliff, J. M.
(2021). Impact of intermediate hyperglycaemia as well as
diabetes on immune dysfunction in tuberculosis.
Clinical Infectious Diseases, 72(1),
69-78. Article ciaa751. https://doi.org/10.1093/cid/ciaa751
Tan,
I. L., Withoff, S., Kolkman, J.
J., Wijmenga, C., Weersma, R.
K., & Visschedijk, M. C. (2021).
Non-classical clinical presentation at diagnosis by male
celiac disease patients of older age. European
Journal of Internal Medicine, 83, 28-33. https://doi.org/10.1016/j.ejim.2020.09.020
BIOS
Consortium, Xu, C.-J., Gruzieva, O., Qi,
C., Esplugues, A., Gehring, U., Bergstroem, A., Mason, D.,
Chatzi, L., Porta, D., Carlsen, K. C. L., Baiz, N., Madore, A.-M.,
Alenius, H., van Rijkom, B., Jankipersadsing, S. A.,
van der Vlies, P., Kull, I., van Hage, M., ... Koppelman, G.
H. (2021). Shared DNA methylation signatures in
childhood allergy: The MeDALL study. Journal of
Allergy and Clinical Immunology, 147(3),
1031-1040. https://doi.org/10.1016/j.jaci.2020.11.044
Hu,
S., Vich Vila, A., Gacesa,
R., Collij, V., Stevens, C., Fu, J. M., Wong,
I., Talkowski, M. E., Rivas, M. A., Imhann, F.,
Bolte, L., van Dullemen, H., Dijkstra,
G., Visschedijk, M. C., Festen, E.
A., Xavier, R. J., Fu, J., Daly, M. J.,
Wijmenga, C., ... Weersma, R. K. (2021).
Whole exome sequencing analyses reveal gene-microbiota
interactions in the context of IBD.
Gut, 70(2), 285-296. Article 319706.
https://doi.org/10.1136/gutjnl-2019-319706
BIOS
Consortium, Ouwens, K. G., Jansen, R., Nivard, M. G., van Dongen,
J., Frieser, M. J., Hottenga, J.-J., Arindrarto, W.,
Claringbould, A., van Iterson, M., Mei, H., &
Franke, L. (2020). A characterization of cis- and
trans-heritability of RNA-Seq-based gene expression.
European Journal of Human Genetics,
28(2), 253-263. https://doi.org/10.1038/s41431-019-0511-5
BIOS
Consortium, Aguirre-Gamboa, R., de Klein,
N., di Tommaso, J., Claringbould, A., van
der Wijst, M. G. P., de Vries, D.,
Brugge, H., Oelen, R., Vosa,
U., Zorro, M. M., Chu, X.,
Bakker, O. B., Borek, Z., Ricano-Ponce,
I., Deelen, P., Xu, C.-J., Swertz,
M., Jonkers, I., ... Li, Y.
(2020). Deconvolution of bulk blood eQTL effects into immune
cell subpopulations. Bmc
Bioinformatics, 21(1), Article 243. https://doi.org/10.1186/s12859-020-03576-5
Chu,
X., Janssen, A. W. M., Koenen, H., Chang, L., He, X.,
Joosten, I., Xu, C., Wijmenga, C., Netea, M., Tack, C.
J., & Li, Y. (2020). Differential genetic and
environmental effects on immune parameters and functions in type 1
diabetes and health. European Journal of Human
Genetics, 28(SUPPL 1), 735-736.
Chen,
L., Schraa, K., van den Munckhof, I. C. L., Ter Horst,
R., Koehorst, M., van Faassen, M., van
der Ley, C., Doestzada, M., Zhernakova, D.
V., Kurilshikov, A., Bloks, V.
W., Groen, A. K., Human Functional Genomics
Project, Riksen, N. P., Rutten, J. H. W., Joosten, L. A. B.,
Wijmenga, C., Zhernakova, A., Netea, M.
G., ... Kuipers, F. (2020). Genetic and
Microbial Associations to Plasma and Fecal Bile Acids in Obesity
Relate to Plasma Lipids and Liver Fat Content.
Cell reports, 33(1), Article 108212.
https://doi.org/10.1016/j.celrep.2020.108212
BBMRI
Metabol Consortium, Pool, R., Hagenbeek, F. A., Hendriks, A. M.,
van Dongen, J., Willemsen, G., de Geus, E., van Dijk, K. W.,
Verhoeven, A., Suchiman, H. E. D., Beekman, M., Slagboom, P. E.,
Harms, A. C., Hankemeier, T., & Boomsma, D. (2020).
Genetics and Not Shared Environment Explains Familial
Resemblance in Adult Metabolomics Data. Twin
research and human genetics, 23(3), 145-155.
https://doi.org/10.1017/thg.2020.53
Kannambath,
S., Jarvis, J. N., Wake, R. M., Longley, N., Loyse, A.,
Matzaraki, V., Aguirre-Gamboa, R.,
Wijmenga, C., Doyle, R., Paximadis, M., Tiemessen, C.
T., Kumar, V., Pittman, A., Meintjes, G., Harrison, T.
S., Netea, M. G., & Bicanic, T. (2020). Genome-Wide
Association Study Identifies Novel Colony Stimulating Factor 1
Locus Conferring Susceptibility to Cryptococcosis in Human
Immunodeficiency Virus-Infected South Africans.
Open Forum Infectious Diseases,
7(11), ofaa489. Article ofaa489. https://doi.org/10.1093/ofid/ofaa489
Chen,
L., Collij, V., Jaeger, M., van den Munckhof,
I. C. L., Vich Vila, A., Kurilshikov,
A., Gacesa, R., Sinha, T.,
Oosting, M., Joosten, L. A. B., Rutten, J. H. W., Riksen, N. P.,
Xavier, R. J., Kuipers, F., Wijmenga,
C., Zhernakova, A., Netea, M. G.,
Weersma, R. K., & Fu, J. (2020). Gut
microbial co-abundance networks show specificity in inflammatory
bowel disease and obesity. Nature
Communications, 11(1), 4018. Article 4018. https://doi.org/10.1038/s41467-020-17840-y
BBMRI
Metabolomics Consortium, Hagenbeek, F. A., Pool, R., van Dongen,
J., Draisma, H. H. M., Jan Hottenga, J., Willemsen, G., Abdellaoui,
A., Fedko, I. O., den Braber, A., Visser, P. J., de Geus, E. J. C.
N., Willems van Dijk, K., Verhoeven, A., Suchiman, H. E., Beekman,
M., Slagboom, P. E., van Duijn, C. M., Harms, A. C., ... Boomsma,
D. I. (2020). Heritability estimates for 361 blood
metabolites across 40 genome-wide association studies.
Nature Communications, 11(1),
Article 39. https://doi.org/10.1038/s41467-019-13770-6
Vich
Vila, A., Collij, V., Sanna,
S., Sinha, T., Imhann, F.,
Bourgonje, A. R., Mujagic, Z., Jonkers, D. M. A. E.,
Masclee, A. A. M., Fu, J., Kurilshikov,
A., Wijmenga, C., Zhernakova,
A., & Weersma, R. K. (2020). Impact
of commonly used drugs on the composition and metabolic function of
the gut microbiota. Nature
Communications, 11(1), Article 362. https://doi.org/10.1038/s41467-019-14177-z
Lifelines
Cohort Study, Lopera Maya, E. A., van der Graaf,
A., Lanting, P., van der Geest,
M., Fu, J., Swertz, M.,
Franke, L., Wijmenga, C., Deelen,
P., Zhernakova, A., & Sanna,
S. (2020). Lack of Association Between Genetic
Variants at ACE2 and TMPRSS2 Genes Involved in SARS-CoV-2 Infection
and Human Quantitative Phenotypes. Frontiers in
Genetics, 11, Article 613. https://doi.org/10.3389/fgene.2020.00613
Warmink-Perdijk,
W. D. B., Peters, L. L., Tigchelaar, E.
F., Dekens, J. A. M., Jankipersadsing, S.
A., Zhernakova, A., Bossers, W. J. R.,
Sikkema, J., de Jonge, A., Reijneveld, S.
A., Verkade, H. J., Koppelman, G.
H., Wijmenga, C., Kuipers,
F., & Scherjon, S. A. (2020).
Lifelines NEXT: a prospective birth cohort adding the next
generation to the three-generation Lifelines cohort study.
European Journal of Epidemiology,
35(2), 157-168. https://doi.org/10.1007/s10654-020-00614-7
BIOS
Consortium, van der Graaf, A., Claringbould,
A., Rimbert, A., Westra,
H.-J., Li, Y., Wijmenga, C.,
Sanna, S., & Franke, L. (2020).
Mendelian randomization while jointly modeling cis genetics
identifies causal relationships between gene expression and
lipids. Nature Communications,
11(1), Article 4930. https://doi.org/10.1038/s41467-020-18716-x
van
den Akker, E. B., Trompet, S., Barkey Wolf, J. J. H., Beekman, M.,
Suchiman, H. E. D., Deelen, J., Asselbergs, F. W., Boersma, E.,
Cats, D., Elders, P. M., Geleijnse, J. M., Ikram, M. A.,
Kloppenburg, M., Mei, H., Meulenbelt, I., Mooijaart, S. P.,
Nelissen, R. G. H. H., Netea, M. G., Penninx, B. W. J. H., ...
Slagboom, P. E. (2020). Metabolic Age Based on the BBMRI-NL
1H-NMR Metabolomics Repository as Biomarker of Age-related
Disease. Circulation. Genomic and precision
medicine, 13(5), 541-547. Article e002610. https://doi.org/10.1161/CIRCGEN.119.002610
Lanting,
P., Drenth, E., Boven, L., van
Hoek, A., Hijlkema, A., Poot, E., van der Vries, G.,
Schoevers, R., Horwitz, E., Gans,
R., Kosterink, J., Plantinga,
M., van Langen, I., Ranchor,
A., Wijmenga, C., Franke,
L., Wilffert, B., & Sijmons,
R. (2020). Practical Barriers and Facilitators
Experienced by Patients, Pharmacists and Physicians to the
Implementation of Pharmacogenomic Screening in Dutch Outpatient
Hospital Care-An Explorative Pilot Study. Journal
of personalized medicine, 10(4), 1-13. Article
293. https://doi.org/10.3390/jpm10040293
Li,
C. M., Zhernakova, A., Engstrand, L., Wijmenga,
C., & Brusselaers, N. (2020). Systematic review
with meta-analysis: the risks of proton pump inhibitors during
pregnancy. Alimentary Pharmacology &
Therapeutics, 51(4), 410-420. https://doi.org/10.1111/apt.15610
Zorro,
M. M., Aguirre-Gamboa, R., Mayassi, T.,
Ciszewski, C., Barisani, D., Hu, S., Weersma, R.
K., Withoff, S., Li, Y.,
Wijmenga, C., Jabri, B., & Jonkers, I. H.
(2020). Tissue alarmins and adaptive cytokine induce dynamic
and distinct transcriptional responses in tissue-resident
intraepithelial cytotoxic T lymphocytes. Journal
of Autoimmunity, 108, Article 102422. https://doi.org/10.1016/j.jaut.2020.102422
2019
Consortium
for the study of genetic associations of celiac disease in
Latin-America, Ricaño-Ponce, I.,
Gutierrez-Achury, J., Costa, A. F., Deelen, P.,
Kurilshikov, A., Zorro, M. M., Platteel,
M., van der Graaf, A., Sanna, S.,
Daffra, O., Zhernakova, A., Fu, J.,
Trynka, G., Smecuol, E., Niveloni, S. I., Bai, J. C., Kumar,
V., & Wijmenga, C. (2020). Immunochip
meta-analysis in European and Argentinian populations identifies
two novel genetic loci associated with celiac disease.
EJHG, 28(3), 313-323. https://doi.org/10.1038/s41431-019-0520-4
Jaeger,
M., Matzaraki, V., Aguirre-Gamboa, R.,
Gresnigt, M. S., Chu, X., Johnson, M. D., Oosting, M.,
Smeekens, S. P., Withoff, S., Jonkers,
I., Perfect, J. R., van de Veerdonk, F. L., Kullberg, B.-J.,
Joosten, L. A. B., Li, Y., Wijmenga, C.,
Netea, M. G., & Kumar, V. (2019). A
Genome-Wide Functional Genomics Approach Identifies Susceptibility
Pathways to Fungal Bloodstream Infection in Humans.
The Journal of Infectious Diseases,
220(5), 862-872. https://doi.org/10.1093/infdis/jiz206
Sinha,
T., Vila, A. V., Garmaeva,
S., Jankipersadsing, S. A., Imhann,
F., Collij, V., Bonder, M. J.,
Jiang, X., Gurry, T., Alm, E. J., D'Amato, M., Weersma, R.
K., Scherjon, S., Wijmenga,
C., Fu, J., Kurilshikov, A.,
& Zhernakova, A. (2019). Analysis of 1135 gut
metagenomes identifies sex-specific resistome profiles.
Gut Microbes, 10(3), 358-366. https://doi.org/10.1080/19490976.2018.1528822
Klaassen,
M. A. Y., Imhann, F., Collij, V.,
Fu, J., Wijmenga, C., Zhernakova,
A., Dijkstra, G., Festen, E. A.
M., Gacesa, R., Vich Vila,
A., & Weersma, R. K. (2019).
Anti-inflammatory Gut Microbial Pathways Are Decreased During
Crohn's Disease Exacerbations. Journal of Crohn's
and Colitis, 13(11), 1439-1449. https://doi.org/10.1093/ecco-jcc/jjz077
Clark,
D. W., Okada, Y., Moore, K. H. S., Mason, D., Pirastu, N., Gandin,
I., Mattsson, H., Barnes, C. L. K., Lin, K., Zhao, J. H.,
Deelen, P., Rohde, R., Schurmann, C., Guo, X., Giulianini,
F., Zhang, W., Medina-Gomez, C., Karlsson, R., Bao, Y., ... Wilson,
J. F. (2019). Associations of autozygosity with a broad range
of human phenotypes. Nature
Communications, 10(1), Article 4957. https://doi.org/10.1038/s41467-019-12283-6
Jaeger,
M., Pinelli, M., Borghi, M., Constantini, C., Dindo, M., van Emst,
L., Puccetti, M., Pariano, M., Ricaño-Ponce, I.,
Büll, C., Gresnigt, M. S., Wang, X., Gutierrez Achury, J.,
Jacobs, C. W. M., Xu, N., Oosting, M., Arts, P., Joosten, L. A. B.,
van de Veerdonk, F. L., ... Netea, M. G. (2019). A systems
genomics approach identifies SIGLEC15 as a susceptibility factor in
recurrent vulvovaginal candidiasis. Science
Translational Medicine, 11(496), Article 3558.
https://doi.org/10.1126/scitranslmed.aar3558
Franzosa,
E. A., Sirota-Madi, A., Avila-Pacheco, J., Fornelos, N., Haiser, H.
J., Reinker, S., Vatanen, T., Hall, A. B., Mallick, H., McIver, L.
J., Sauk, J. S., Wilson, R. G., Stevens, B. W., Scott, J. M.,
Pierce, K., Deik, A. A., Bullock, K., Imhann, F.,
Porter, J. A., ... Xavier, R. J. (2019). Author Correction:
Gut microbiome structure and metabolic activity in inflammatory
bowel disease. Nature Microbiology,
4(5), 898. https://doi.org/10.1038/s41564-019-0442-5
Sanna,
S., van Zuydam, N. R., Mahajan, A., Kurilshikov,
A., Vich Vila, A., Võsa, U.,
Mujagic, Z., Masclee, A. A. M., Jonkers, D. M. A. E., Oosting, M.,
Joosten, L. A. B., Netea, M. G., Franke, L.,
Zhernakova, A., Fu, J., Wijmenga,
C., & McCarthy, M. I. (2019). Causal relationships
among the gut microbiome, short-chain fatty acids and metabolic
diseases. Nature Genetics,
51(4), 600-605. https://doi.org/10.1038/s41588-019-0350-x
Moerkens,
R., Mooiweer, J., Withoff,
S., & Wijmenga, C. (2019). Celiac
disease-on-chip: Modeling a multifactorial disease in vitro.
United European Gastroenterology Journal,
7(4), 467-476. https://doi.org/10.1177/2050640619836057
Mayassi,
T., Ladell, K., Gudjonson, H., McLaren, J. E., Shaw, D. G., Tran,
M. T., Rokicka, J. J., Lawrence, I., Grenier, J.-C., van Unen, V.,
Ciszewski, C., Dimaano, M., Sayegh, H. E., Kumar,
V., Wijmenga, C., Green, P. H. R., Gokhale, R.,
Jericho, H., Semrad, C. E., ... Jabri, B. (2019). Chronic
Inflammation Permanently Reshapes Tissue-Resident Immunity in
Celiac Disease. Cell, 176(5),
967-981,e19. https://doi.org/10.1016/j.cell.2018.12.039
BIOS
Consortium, van Dongen, J., Zilhao, N. R., Sugden, K., Hannon, E.
J., Mill, J., Caspi, A., Agnew-Blais, J., Arseneault, L., Corcoran,
D. L., Moffitt, T. E., Poulton, R., Franke, B., & Boomsma, D.
(2019). Epigenome-wide Association Study of
Attention-Deficit/Hyperactivity Disorder Symptoms in Adults.
Biological Psychiatry, 86(8),
599-607. https://doi.org/10.1016/j.biopsych.2019.02.016
Le,
K. T. T., Matzaraki, V., Netea, M. G.,
Wijmenga, C., Moser, J., & Kumar,
V. (2019). Functional Annotation of Genetic Loci
Associated With Sepsis Prioritizes Immune and Endothelial Cell
Pathways. Frontiers in Immunology,
10, Article 1949. https://doi.org/10.3389/fimmu.2019.01949
Myositis
Genetics Consortium, Scleroderma Genetics Consortium,
Acosta-Herrera, M., Kerick, M., Gonzalez-Serna, D., Wijmenga,
C., Franke, A., Gregersen, P. K., Padyukov, L., Worthington,
J., Vyse, T. J., Eugenia Alarcon-Riquelme, M., Mayes, M. D., &
Martin, J. (2019). Genome-wide meta-analysis reveals shared
new loci in systemic seropositive rheumatic diseases.
Annals of the Rheumatic Diseases,
78(3), 311-319. https://doi.org/10.1136/annrheumdis-2018-214127
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